Methods of stimulating immune response in certain individuals

Abstract

The present invention is directed to a method of increasing the time period between outbreaks of genital herpes comprising providing an imidazoquinolinamine formulation, disposing an amount of the imidazoquinolinamine formulation into a first nare of an individual infected with Herpes Simplex Virus type 2, covering at least a portion of the internal surface of the individual's first nare with a portion of the amount of the imidazoquinolinamine in the nare, massaging the portion of the amount of the imidazoquinolinamine into the internal surface of the first nare, disposing the amount of the imidazoquinolinamine formulation into a second nare of the individual, covering at least a portion of the internal surface of the second nare with a portion of the amount of the imidazoquinolinamine in said nare and massaging the portion of the amount of the imidazoquinolinamine into the internal surface of said nare.

1 . A method of stimulating an immune response in an individual affected with a cancer, the method consisting essentially of:
 providing an imidazoquinolinamine formulation;   disposing an amount of the imidazoquinolinamine formulation into a first naris of a virally infected individual; and   covering at least a portion of the internal surface of the individual's first naris with a portion of the amount of imidazoquinolinamine in said naris.   
     
     
         2 . The method of  claim 1  wherein the cancer is lung cancer. 
     
     
         3 . The method of  claim 1  wherein the cancer is bronchogenic carcinoma. 
     
     
         4 . The method of  claim 1  wherein the cancer is bronchoalveolar carcinoma. 
     
     
         5 . The method of  claim 1  wherein the cancer is nasal type natural killer T cell lymphoma. 
     
     
         6 . The method of  claim 1 , wherein the imidazoquinolinamine formulation's active ingredient is selected from the group consisting of imiquimod and resiquimod. 
     
     
         7 . The method of  claim 1 , wherein the imidazoquinolinamine formulation is disposed using a device selected from the group consisting of a swab, syringe, spray nozzle, and a drip applicator. 
     
     
         8 . The method of  claim 1 , wherein the imidazoquinolinamine formulation comprises imiquimod as an active ingredient in the amount of about 3 mg. 
     
     
         9 . The method of  claim 1 , wherein the imidazoquinolinamine formulation comprises resiquimod as an active ingredient in the amount of about 3 mg. 
     
     
         10 . The method of  claim 1 , wherein the imidazoquinolinamine formulation is selected from a group consisting of a cream, gel, liquid, paste, aerosol, and an emulsion. 
     
     
         11 . A product for stimulating an immune response in an individual affected with cancer consisting essentially of:
 an imidazoquinolinamine formulation; and   an instruction set, wherein the instruction set directs the individual to dispose an amount of the imidazoquinolinamine formulation into a first naris of the individual and to cover at least a portion of the internal surface of the first naris with a portion of the imidazoquinolinamine in the naris.