Oxygenated Ophthalmic Compositions and Methods of Use

Abstract

The present invention relates to oxygenated ophthalmic topical compositions and methods of administering oxygenated ophthalmic topical compositions. The present invention also encompasses methods for making and administering the oxygenated ophthalmic topical compositions for use in treating or ameliorating pathologic conditions, complications, diseases and symptoms related to hypoxia of the anterior eye structure, including corneal neovascularization (CNV), edema, abrasions, infections, infiltrates, dry eye syndrome, contact lens intolerance; and redness, blurred vision, discomfort, foreign body sensation, photophobia, and irritation.

1 . A method of treating an ocular condition comprising administering an ophthalmic composition comprising a solution of an aqueous ophthalmic agent containing oxygen via topical ocular administration to a patient in need thereof, wherein the composition is administered from a single-dose container. 
     
     
         2 . The method of  claim 1  wherein the ocular condition is ocular hypoxia. 
     
     
         3 . The method of  claim 1  wherein the ocular condition is contact lens intolerance syndrome. 
     
     
         4 . The method of  claim 1  wherein the ocular condition is corneal neovascularization. 
     
     
         5 . The method of claim I wherein the ocular condition is one or more corneal abrasion. 
     
     
         6 . The method of claim I wherein the ocular condition is hypoxia of one or more of the anterior eye structures. 
     
     
         7 . The method of  claim 1  wherein the ocular condition is ocular pathology. 
     
     
         8 . The method of  claim 2 , wherein the administration of said solution is from a single-dose container wherein any space not utilized by the aqueous ophthalmic agent is filled with oxygen gas. 
     
     
         9 . The method of  claim 8  wherein the aqueous ophthalmic agent contains approximately 13.5 ml oxygen per liter of solution. 
     
     
         10 . A method of treatment of eye irritation caused by an eye procedure, comprising administering an ophthalmic composition comprising a solution of an aqueous ophthalmic agent containing oxygen via topical ocular administration to a patient in need of such treatment. 
     
     
         11 . The method of  claim 10 , wherein the eye procedure is selected from the group consisting of LASEK and LASIK surgery. 
     
     
         12 . The method of  claim 10 , wherein the aqueous ophthalmic agent is administered from a single dose container. 
     
     
         13 . The method of treatment of ocular hypoxia, comprising administering an ophthalmic composition comprising an ophthalmic agent containing oxygen via topical ocular administration to a patient in need thereof wherein the ophthalmic agent is selected from the group consisting of an antibacterial agent, an antiviral agent, a corticosteroid, a dilating agent, a glaucoma agent, a mydriatic, a cycloplegic, a non-steroidal anti-inflammatory drug (NSAID), an ocular antihistamine, an ocular decongestant, an ocular MAST cell stabilizer, an allergy agent, and combinations thereof. 
     
     
         14 . The method of  claim 13 , wherein the ocular hypoxia is intraocular hypoxia. 
     
     
         15 . The method of  claim 13 , wherein the hypoxia is of one or more of the anterior eye structures.