Biocompatible polymer and magnetic nanoparticle with biocompatibility

Abstract

The invention discloses a biocompatible polymer for covalently modifying magnetic nanoparticles. The biocompatible polymer may be coupled to a targeting agent and/or a fluorescent dye. The invention also discloses a magnetic nanoparticle with biocompatibilities comprising the biocompatible polymer.

1 . A biocompatible polymer of formula (I), 
       
         
           
           
               
               
           
         
         wherein R 1  is alkyl, aryl, carboxyl, or amino; 
         R 2  is alkyl or aryl; 
         n is an integer from 5 to 1000; and 
         m is an integer from 1 to 10. 
       
     
     
         2 . The biocompatible polymer as claimed in  claim 1 , wherein each of R 1  and R 2  independently is a C 1 -C 20  straight chain or branched alkyl. 
     
     
         3 . The biocompatible polymer as claimed in  claim 1 , wherein each of R 1  and R 2  independently is a C 6 -C 12  substituted or unsubstituted aryl. 
     
     
         4 . The biocompatible polymer as claimed in  claim 1 , wherein R 1  is methyl. 
     
     
         5 . The biocompatible polymer as claimed in  claim 1 , wherein R 2  is ethyl. 
     
     
         6 . The biocompatible polymer as claimed in  claim 1 , wherein n is 15. 
     
     
         7 . The biocompatible polymer as claimed in  claim 1 , wherein m is 3. 
     
     
         8 . A magnetic nanoparticle with bio compatibility, comprising:
 a magnetic nanoparticle;   a biocompatible polymer of formula (II) covalently coupled to the magnetic nanoparticle,   
       
         
           
           
               
               
           
         
         wherein R 1  is alkyl, aryl, carboxyl, or amino; 
         n is an integer from 5 to 1000; and 
         m is an integer from 1 to 10. 
       
     
     
         9 . The magnetic nanoparticle with biocompatibility as claimed in  claim 8 , wherein R 1  is carboxyl or amino. 
     
     
         10 . The magnetic nanoparticle with biocompatibility as claimed in  claim 8 , wherein the magnetic nanoparticle is a superparamagnetic nanoparticle. 
     
     
         11 . The magnetic nanoparticle with biocompatibility as claimed in  claim 8 , wherein the magnetic nanoparticle comprises at least one of Fe, Co, Ni, and oxides thereof. 
     
     
         12 . The magnetic nanoparticle with biocompatibility as claimed in  claim 9 , wherein R 1  is coupled to a specific targeting agent comprising an antibody, a protein, a peptide, an enzyme, a carbohydrate, a glycoprotein, a nucleotide or a lipid. 
     
     
         13 . The magnetic nanoparticle with biocompatibility as claimed in  claim 12 , wherein the magnetic nanoparticle has a diameter of about 3-500 nm. 
     
     
         14 . The magnetic nanoparticle with biocompatibility as claimed in  claim 12 , wherein the biocompatible polymer is coupled to a fluorescent dye. 
     
     
         15 . The magnetic nanoparticle with biocompatibility as claimed in  claim 14 , wherein the magnetic nanoparticle containing the fluorescent dye and the specific targeting agent has a diameter of about 15-200 nm. 
     
     
         16 . The magnetic nanoparticle with biocompatibility as claimed in  claim 14 , wherein the fluorescent dye exhibits at least one of ultraviolet (UV), near-infrared (NIR), and visible (VIS) light excitation or emission wavelength. 
     
     
         17 . The magnetic nanoparticle with biocompatibility as claimed in  claim 14 , wherein the fluorescent dye comprises an organic dye, an inorganic dye, or an organometallic complex. 
     
     
         18 . The magnetic nanoparticle with biocompatibility as claimed in  claim 14 , wherein the fluorescent dye and the specific targeting agent are coupled to the biocompatible polymer by a covalent bond. 
     
     
         19 . The magnetic nanoparticle with biocompatibility as claimed in  claim 14 , wherein the specific targeting agent and the biocompatible polymer are coupled by a —CONH— linkage. 
     
     
         20 . The magnetic nanoparticle with biocompatibility as claimed in  claim 8 , wherein the biocompatible polymer is coated on the magnetic nanoparticle to form a core/shell structure. 
     
     
         21 . The magnetic nanoparticle with biocompatibility as claimed in  claim 20 , wherein the biocompatible polymer forms a monolayer coating on the magnetic nanoparticle.