Thienopyrazole derivative having pde7 inhibitory activity

Abstract

To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: —CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].

1 - 21 . (canceled) 
     
     
         22 . A compound of the formula (IV): 
       
         
           
           
               
               
           
         
       
       wherein
 R 1  is substituted or unsubstituted C 3 -C 8  alkyl group, substituted or unsubstituted cycloalkyl group or substituted or unsubstituted heterocycloalkyl group; 
 R 2  is a hydrogen atom or C 1 -C 2  alkyl group; 
 and R 3  is a hydrogen atom. 
 
     
     
         23 . (canceled)