Antiallergic composition

Abstract

An antiallergic composition that is moderate for the human body and skin, and has reduced side-effects that comprises a cold-water extract from hop tissue or flavonoid glucosides separated from the cold-water extract from hop tissue.

1 - 16 . (canceled) 
     
     
         17 . An isolated or purified composition comprising a cold-water extract of hop tissue. 
     
     
         18 . The composition according to  claim 17 , wherein the hop tissue is beer brewing hop tissue. 
     
     
         19 . The composition according to  claim 17 , wherein the hop tissue is from hop stems, cones or leaves. 
     
     
         20 . The composition according to  claim 17 , wherein the hop tissue is a ground product of dried bract. 
     
     
         21 . The composition according to  claim 17 , wherein the hop tissue is a ground product of dried cones from which at least a portion including lupulin and smaller components has been removed. 
     
     
         22 . The composition according to  claim 21 , wherein the ground product of dried cones is a ground product of frozen dried cones. 
     
     
         23 . The composition according to  claim 17 , wherein the hop tissue is hop residue obtained by removing at least a portion of the substances that are extracted by organic solvent extraction or supercritical fluid extraction from dried cones. 
     
     
         24 . The composition according to  claim 17 , wherein the cold-water extract contains flavonoid glucosides. 
     
     
         25 . The composition comprising flavonoid glucosides separated from a cold-water extract of hop tissue. 
     
     
         26 . The composition according to  claim 25 , wherein the flavonoid glucosides are flavonol glucosides. 
     
     
         27 . The composition according to  claim 26 , which contains kaempferol glucosides as the flavonol glucosides. 
     
     
         28 . The composition according to  claim 27 , wherein the kaempferol glucosides are one or more selected from the group consisting of kaempferol rutinoside, astragalin and kaempferol malonylglucoside. 
     
     
         29 . The composition according to  claim 28  which further comprises quercetin malonylglucosides as the flavonol glucosides. 
     
     
         30 . The composition of  claim 17  wherein the cold-water extract has been produced using cold water between 0° C. and 50° C. 
     
     
         31 . The composition of  claim 17  wherein the cold-water extract has been produced using cold water between 0° C. and 30° C. 
     
     
         32 . The composition of  claim 17  wherein the cold-water extract has been produced using cold water between 0° C. and 10° C. 
     
     
         33 . The composition of  claim 17  wherein the cold-water extract has been produced using a solution of cold water and alcohol, wherein the alcohol content does not exceed 10 wt. %. 
     
     
         34 . A drug comprising as an active ingredient the composition according to  claim 17 . 
     
     
         35 . A cosmetic comprising the composition according to  claim 17 . 
     
     
         36 . A food or beverage comprising the composition according to  claim 17 . 
     
     
         37 . A method for inhibiting release of a pharmacologically active amine or serotonin or both comprising administering the composition of  claim 17  to a subject in need thereof. 
     
     
         38 . The method of  claim 37 , wherein said subject has an allergic condition. 
     
     
         39 . A method of making the composition of  claim 17 , comprising immersing hop tissue in water at a temperature ranging from 0° C. to 50° C. to obtain a liquid extract, and
 separating the liquid extract from solid components. 
 
     
     
         40 . The method of  claim 39 , comprising immersing the hop tissue in water at a temperature raging from 0° C. to 30° C. 
     
     
         41 . The method of  claim 39 , comprising immersing the hop tissue in water at a temperature raging from 2° C. to 8° C.