US2011160278A1PendingUtilityA1

Methods For Selectively Modulating Survivin Apoptosis Pathways

64
Individually held — no corporate assignee on recordPriority: Feb 29, 2000Filed: May 20, 2009Published: Jun 30, 2011
Est. expiryFeb 29, 2020(expired)· nominal 20-yr term from priority
Inventors:Dario C. Altieri
C07K 16/18G01N 33/5011A61P 43/00C12Q 1/485A61P 35/00G01N 2500/00
64
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Claims

Abstract

The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34 cdc2 -cyclin B1 kinase complex, and the interaction between survivin and caspase-9. Related methods and compositions can be used to modulate survivin regulated apoptosis.

Claims

exact text as granted — not AI-modified
1 - 29 . (canceled) 
     
     
         30 . A method of inhibiting the growth of a tumor cell comprising administering an effective amount of an antisense survivin nucleic acid to the tumor cell. 
     
     
         31 . The method of  claim 30 , wherein the tumor cell is in a tumor mass. 
     
     
         32 . The method of  claim 31 , wherein the tumor mass is present in a mammal. 
     
     
         33 . The method of  claim 32 , wherein the tumor mass is a melanoma. 
     
     
         34 . The method of  claim 31 , wherein the method inhibits the growth of a tumor mass in vivo. 
     
     
         35 . The method of  claim 30 , wherein the method inhibits the growth of a tumor cell in vitro. 
     
     
         36 . The method of  claim 30 , wherein the method inhibits the growth of a tumor cell is in vivo.

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