Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance

Abstract

The present invention relates to a mucoadhesive composition, adapted for preventing and/or treating a pathological reaction of the immune system of an individual, by inducing a specific tolerance towards at least one antigen involved in said pathological reaction, comprising chitosan particles loaded with said at least one antigen involved in the pathological reaction, wherein the size of the loaded chitosan particles is of more than 800 nm.

1 . A mucoadhesive composition adapted for preventing and/or treating a pathological reaction of the immune system of an individual by inducing a specific tolerance towards at least one antigen involved in said pathological reaction, comprising chitosan particles loaded with said at least one antigen involved in the pathological reaction, wherein the size of the loaded chitosan particles is of more than 800 nm. 
     
     
         2 . The mucoadhesive composition according to  claim 1 , wherein the size of the loaded chitosan particles is from 1 μm to 3 μm. 
     
     
         3 . The mucoadhesive composition according to  claim 1 , wherein the zeta potential of the loaded chitosan particles is of more than 2.5 mV. 
     
     
         4 . The mucoadhesive composition according to  claim 1 , wherein the zeta potential of the loaded chitosan particles is of from 6 to 9 mV. 
     
     
         5 . The mucoadhesive composition according to  claim 1 , wherein the antigen is selected from the group consisting of an allergen, an auto-antigen and a graft-specific antigen. 
     
     
         6 . The mucoadhesive composition according to  claim 1 , wherein the antigen is an allergen. 
     
     
         7 . The mucoadhesive composition according to  claim 6 , wherein said allergen is selected from the group consisting of pollen allergens, mite allergens, insect allergens, animal hair and dandruff allergens, and food allergens. 
     
     
         8 . An immunotherapeutic composition comprising a mucoadhesive composition as defined in  claim 1 , in association with pharmaceutically acceptable carrier. 
     
     
         9 . An immunotherapeutic composition according to  claim 8 , in the form of a suspension, a gel, a powder, a tablet, a capsule, or a lyoc. 
     
     
         10 . An immunotherapeutic composition according to  claim 8 , further comprising an adjuvant for enhancing antigen-specific tolerance induction. 
     
     
         11 . A mucoadhesive composition as defined in  claim 1 , for use as a medicament for the prevention and/or the treatment of a pathological reaction of the immune system of an individual by inducing a specific tolerance towards at least one antigen involved in said pathological reaction. 
     
     
         12 . The mucoadhesive composition or the immunotherapeutic composition in its application according to  claim 11 , wherein the pathological reaction is selected from allergy, autoimmune disease or graft rejection. 
     
     
         13 . The mucoadhesive composition or the immunotherapeutic composition in its application according to  claim 11 , wherein the medicament is to be administered by the mucosal route. 
     
     
         14 . The mucoadhesive composition or the immunotherapeutic composition in its application according to  claim 11 , wherein the medicament is to be administered via the oromucosal route. 
     
     
         15 . The mucoadhesive composition or the immunotherapeutic composition in its application according to  claim 11 , wherein the medicament is to be administered via the sublingual route. 
     
     
         16 . An immunotherapeutic composition according to  claim 8 , for use as a medicament for the prevention and/or the treatment of a pathological reaction of the immune system of an individual by inducing a specific tolerance towards at least one antigen involved in said pathological reaction.