Compositions and methods for treatment of vitiligo

Abstract

Compositions and methods are disclosed for treating vitiligo and promoting the formation of collagen.

1 . A composition comprising: a) a cosmeceutically acceptable medium and b) a cosmeceutically effective amount of rapamycin. 
     
     
         2 . A composition comprising: a) a cosmeceutically acceptable medium and b) a cosmeceutically effective amount of rapamycin wherein the product reduces the T-cell induced degradation of melanocytes. 
     
     
         3 . A composition according to  claim 1 , further comprising fibroblast growth factor, wherein the composition promotes the formation of collagen. 
     
     
         4 . A composition according to  claim 1 , further comprising vitamin E. 
     
     
         5 . A composition according to  claim 1 , further comprising tromethamine, glutathione peroxidase, and catalase. 
     
     
         6 . A composition according to  claim 2 , wherein said composition is topically administered. 
     
     
         7 . A composition according to  claim 2 , wherein said composition is formulated as a leave-on product. 
     
     
         8 . A composition according to  claim 2 , wherein the product is rapamycin and the cosmeceutically effective amount consists of about 0.001 to 0.5 weight percent of the composition. 
     
     
         9 . A composition according to  claim 2 , wherein the cosmeceutically effective amount consists of about 0.1 to 0.2 weight percent of the composition. 
     
     
         10 . A composition according to  claim 2 , wherein the cosmeceutically effective amount consists of about 0.15 weight percent of the composition. 
     
     
         11 . A method of treating vitiligo comprising the step of: topically administering a composition of  claim 2  to a person in need thereof. 
     
     
         12 . A method of promoting collagen production comprising the step of: topically administering a composition of  claim 2  to a person in need thereof. 
     
     
         13 . A method of inhibiting T cells in melanocytes comprising the step of: administering an effective amount of rapamycin to the cells, wherein the effective amount consists of about 0.1 uM to 100 uM.