Use of indole compounds as a cosmetic

Abstract

The invention relates to a compound of formula I wherein R 1 , R 2 and R 3 are identical or different and each is H or alkyl of 1-6 carbon atoms, R 4 is H or methyl, R 5 is phenyl or chlorophenyl, and/or physiologically acceptable salts thereof and its use in compositions, especially topical, cosmetic and/or personal care compositions, and compositions containing said compound.

1 ) Composition for topical use comprising a compound of formula of I 
       
         
           
           
               
               
           
         
         wherein 
         R 1 , R 2  and R 3  are identical or different and each is H or alkyl of 1-6 carbon atoms, 
         R 4  is H or methyl, 
         R 5  is phenyl or chlorophenyl, 
         and/or physiologically acceptable salts thereof 
         and one or more topically acceptable vehicles. 
       
     
     
         2 ) Composition according to  claim 1  wherein the compound of formula I is 5-(7-methoxy-3,3-dimethyl-2,3-dihydro-1-benzoxepin-5-yl)-3-methyl-penta-2,4-dienoic and/or a physiologically acceptable salt thereof. 
     
     
         3 ) Composition for topical use comprising
 a) active ingredient according to  claim 1 ,   b) one or more skin-tolerated vehicles, and   c) optionally one or more further active compounds having a skin-care and/or inflammation-inhibiting action.   
     
     
         4 ) Composition according to  claim 1 , wherein the active ingredient is contained in said composition in an amount of 0.00001 percent by weight to 10 percent by weight. 
     
     
         5 ) Composition according to  claim 1 , comprising at least one further skin-care ingredient and at least one carrier which is suitable for topical applications. 
     
     
         6 ) Composition according to  claim 5 , comprising as a further skin-care ingredient ectoine, preferably in an amount of 0.01 to 10 percent by weight, more preferably 0.1 to 5 percent by weight and especially 0.1 to 2 percent by weight. 
     
     
         7 ) A composition according to  claim 1 , which is a cosmetic composition. 
     
     
         8 ) A method for the prophylaxis and/or treatment of skin diseases which are associated with defective keratinisation relating to differentiation and cell proliferation, in particular for the treatment of acne vulgaris, acne comedonica, polymorphic acne, acne rosaceae, nodular acne, acne conglobata, age-related acne, acne occurring as a side effect, such as acne solaris, medicament-related acne or acne professionalis, for the treatment of other defects of keratinisation, in particular ichthyosis, ichthyosiform states, Darier's disease, keratosis palmoplantaris, leukoplakia, leukoplakiform states, skin and mucosal (buccal) eczema (lichen), for the treatment of other skin diseases which are associated with defective keratinisation and have an inflammatory and/or immunoallergic component, and in particular all forms of psoriasis relating to the skin, mucous membranes and finger- and toenails, and psoriatic rheumatism and skin atopy, such as eczema, or respiratory atopy, or also hypertrophy of the gums comprising administering to a subject in need thereof a composition according to  claim 1 . 
     
     
         9 ) A method according to  claim 8  for hair care and/or hair follicle development. 
     
     
         10 ) A method for the care, preservation or improvement of the general state of the skin or hair, comprising administering to a subject in need thereof a composition according to  claim 1 . 
     
     
         11 ) A method for skin lightening and/or skin whitening, comprising administering to a subject in need thereof a composition according to  claim 1 . 
     
     
         12 ) A method for skin lightening and/or skin whitening, comprising administering to a subject in need thereof a composition according to  claim 1 . 
     
     
         13 ) A method for the prophylaxis against or reduction of skin unevenness, such as wrinkles, fine lines, rough skin or large-pored skin comprising administering to a subject in need thereof a composition according to  claim 1 . 
     
     
         14 ) A method for the prophylaxis against time- and/or light-induced ageing processes of the human skin or human hair, in particular for prophylaxis against dry skin, wrinkle formation and/or pigment defects, and/or for the reduction or prevention of the harmful effects of UV rays on the skin comprising administering to a subject in need thereof a composition according to  claim 1 .