Polymer for filler for preprocessing column

Abstract

It is a subject of the present invention to provide a novel polymer; a filler for measuring a perfluoro compound having an acidic group at terminal which comprises said polymer; a column filled with said filler; and a measuring method for a perfluoro compound having an acidic group at terminal by using said column; as well as a filler for measuring a drug comprising the above-described polymer; a column filled with said filler; and a measuring method for a drug by using said column. The present invention relates to a polymer obtained by introducing an anion exchanging group to a glycidyl group in a polymer obtained by polymerizing the compound represented by the following general formula [1]: and the compound represented by the following general formula [2]: a filler (column) for measuring an acidic group binding perfluoro compound at terminal which comprises said polymer; a method for measuring said perfluoro compound by using said column; a filler (column) for measuring a drug which comprises the above-described polymer; and a method for measuring a drug by using said column.

1 . A polymer obtained by introducing an anion exchanging group to a glycidyl group of a polymer obtained by polymerizing a compound represented by the following general formula [1]: 
       
         
           
           
               
               
           
         
       
       (wherein each of R 1  and R 2  independently represents a hydrogen atom, a linear alkyl group having 1 to 3 carbon atoms or a halogen atom, Bz represents benzene ring), and a compound represented by the following general formula [2]: 
       
         
           
           
               
               
           
         
       
       (wherein R 9  represents a hydrogen atom, a linear alkyl group having 1 to 3 carbon atoms or a halogen atom, R 10  represents a linear alkylene group having 1 to 3 carbon atoms, each of R 11  and R 12  independently represents a hydrogen atom or a linear alkyl group having 1 to 6 carbon atoms). 
     
     
         2 . The polymer according to  claim 1 , wherein the anion exchanging group is a tertiary amino group. 
     
     
         3 . The polymer according to  claim 1 , wherein the anion exchanging group is a morpholino group or a diethylamino group. 
     
     
         4 . The polymer according to  claim 1 , wherein the compound represented by the general formula [1] is divinylbenzene. 
     
     
         5 . The polymer according to  claim 1 , wherein the compound represented by the general formula [2] is the compound represented by the following general formula [2′]: 
       
         
           
           
               
               
           
         
       
     
     
         6 . A filler for measuring a perfluoro compound having an acidic group at terminal, comprising the polymer according to  claim 1 . 
     
     
         7 . The filler according to  claim 6 , wherein the acidic group at terminal of the perfluoro compound is a carboxyl group or a sulfo group. 
     
     
         8 . A preprocessing column for measuring a perfluoro compound having the acidic group at terminal which is filled with the filler according to  claim 6 . 
     
     
         9 . A measuring method for measuring a perfluoro compound having an acidic group at terminal, characterized in using the column according to  claim 8 . 
     
     
         10 . A measuring method for a perfluoro compound comprising a step for adsorbing said perfluoro compound by passing the sample containing said perfluoro compound having an acidic group at terminal to the column according to  claim 8 ; a step for eluting said perfluoro compound by eluate; and a step for measuring the obtained perfluoro compound. 
     
     
         11 . The polymer according to  claim 1 , wherein the anion exchanging group is an ammonium group represented by the following general formula [3]: 
       
         
           
           
               
               
           
         
       
       (wherein each of R 3  represents independently a linear alkyl group having 1 to 3 carbon atoms, R 4  represents a linear alkyl group having 1 to 6 carbon atoms). 
     
     
         12 . The polymer according to  claim 11 , wherein R 3  represents a methyl group and R 4  represents an ethyl group in the general formula [3]. 
     
     
         13 . The polymer according to  claim 11 , wherein said polymer is obtained by introducing the ammonium group represented by the general formula [3] to the glycidyl group in the polymer obtained by polymerizing monomers containing the compound represented by the general formula [1] and the compound represented by the general formula [2] and further the compound represented by the following general formula [4]: 
       
         
           
           
               
               
           
         
       
       (wherein each of three R 15  represents independently a linear alkylene group having 1 to 3 carbon atoms, each of three R 16  independently represents a hydrogen atom, a linear alkyl group having 1 to 3 carbon atoms or a halogen atom). 
     
     
         14 . The polymer according to  claim 13 , wherein R 15  in the general formula [4] is a methylene group and R 16  is a hydrogen atom. 
     
     
         15 . The polymer according to  claim 11 , wherein the compound represented by the general formula [1] is divinylbenzene. 
     
     
         16 . The polymer according to  claim 11 , wherein the compound represented by the general formula [2] is the compound represented by the following general formula [2′]: 
       
         
           
           
               
               
           
         
       
     
     
         17 . A filler for measuring drugs which comprises the polymer according to  claim 11 . 
     
     
         18 . A preprocessing column filled with the filler according to  claim 17 . 
     
     
         19 . A measuring method of a drug characterized in using the column according to  claim 18 . 
     
     
         20 . A measuring method of a drug comprising a step for adsorbing said drug by passing the sample containing said drug to the column according to  claim 18 ; a step for eluting said drug by eluate; and a step for measuring the eluted drug.