US2011124715A1PendingUtilityA1

Antiviral Oligonucleotides Having a Conserved G4 Core Sequence

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Individually held — no corporate assignee on recordPriority: Sep 29, 1992Filed: Aug 4, 2010Published: May 26, 2011
Est. expirySep 29, 2012(expired)· nominal 20-yr term from priority
Inventors:Ronnie HanecakKevin P. AndersonC. Frank BennettMing-Yi ChiangVickie Brown-DriverDavid J. EckerTimothy VickersJacqueline Wyatt
A61P 31/16A61P 31/12A61P 35/00A61P 31/18A61P 31/22C07H 21/00A61K 38/00C12Y 301/01004C12N 2310/341A61K 31/70C12N 2310/151C12N 2310/315C12Q 1/701C12N 15/1137C12N 15/117C12N 2310/18C12N 15/1133C12N 15/115C12N 2310/346C12Y 207/07049C12N 2310/321C12Q 1/68A01N 43/04C12Q 1/70
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Claims

Abstract

Modified oligonucleotides having a conserved G 4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus are provided. G 4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases are also provided.

Claims

exact text as granted — not AI-modified
1 . A method for inhibiting the activity of a virus comprising contacting the virus with a chemically modified oligonucleotide having no more than 27 nucleic acid base units comprising at least one GGGG sequence or at least two GGG sequences and a sufficient number of flanking nucleotides to significantly inhibit the activity of the virus. 
     
     
         2 . The method of  claim 1  wherein the virus is HIV, HSV, HCMV or an influenza virus. 
     
     
         3 . The method of  claim 2  wherein significant inhibition of viral activity is at least 50% inhibition. 
     
     
         4 . The method of  claim 2  wherein the oligonucleotide has the sequence TTGGGGTT. 
     
     
         5 . The method of  claim 4  wherein said oligonucleotide has at least one phosphorothioate intersugar (backbone) linkage.

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