Wound Dressings Containing Complexes of Transition Metals and Alginate for Elastase-Sequestering

Abstract

Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration.

1 - 5 . (canceled) 
     
     
         6 . A wound dressing comprising:
 a polysaccharide substrate; and   an alginate coating mixed with at least one transition metal.   
     
     
         7 . A method for treating a wound, comprising:
 contacting a wound with a wound dressing comprising a polysaccharide substrate with an alginate coating;   absorbing wound fluid with said wound dressing; and   sequestering elastase from said wound.   
     
     
         8 . The method of  claim 7  wherein said polysaccharide substrate is phosphorylated and is complexed with at least one transition metal. 
     
     
         9 . The method of  claim 7  wherein said alginate coating is mixed with at least one transition metal. 
     
     
         10 . A wound dressing, comprising:
 (A) a phosphorylated polysaccharide substrate complexed with at least one transition metal, wherein the polysaccharide substrate comprises:
 a soluble aldehydic polysaccharide 
 dialdehyde starch; 
 phosphorylated cotton; 
 phosphorylated starch; 
 carboxymethyl cellulose; 
 dialdehyde gauze or 
 sulfonated gauze 
   
       and
 (B) an alginate coating. 
 
     
     
         11 . A wound dressing, comprising:
 a phosphorylated polysaccharide substrate complexed with at least one transition metal; and   an alginate coating, wherein the alginate coating comprises an alginate selected from the group consisting of ammonium alginate, sodium alginate, potassium alginate, magnesium alginate and alginic acid.   
     
     
         12 . The wound dressing of  claim 11 , wherein the alginate coating comprises ammonium alginate. 
     
     
         13 . A wound dressing comprising:
 (A) a phosphorylated polysaccharide substrate complexed with at least one transition metal, wherein the polysaccharide substrate comprises:
 a soluble aldehydic polysaccharide; 
 dialdehyde starch; 
 phosphorylated cotton; 
 phosphorylated starch; 
 carboxymethyl cellulose; 
 dialdehyde gauze; or 
 sulfonated gauze; 
   
       and
 (B) an alginate coating wherein said alginate coating is crosslinked. 
 
     
     
         14 . A wound dressing comprising:
 a phosphorylated polysaccharide substrate complexed with at least one transition metal; and   an alginate coating wherein said alginate coating is crosslinked, wherein the alginate coating comprises an alginate selected from the group consisting of ammonium alginate, sodium alginate, potassium alginate, magnesium alginate and alginic acid.   
     
     
         15 . The wound dressing of  claim 14 , wherein the alginate coating comprises ammonium alginate.