Encapsulated or coated stent systems

Abstract

A stent system comprising zero or more inner stents inserted into an outer stent. The inner stents and outer stent are separated and/or encapsulated by a protein-based material of a protein matrix and/or a set biocoacervate, each comprising one or more biocompatible proteins and one or more biocompatible solvents. The protein-based material may also include one or more carbohydrates and one or more pharmacologically active agents.

1 . A stent system comprising:
 two or more metallic or polymeric stents that are fitted to be inserted into each other; and   a protein based material coating or encapsulating the one or more of the metallic or polymeric stents, the protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents.   
     
     
         2 . The stent system of  claim 1  wherein the protein based material is a protein matrix material or a biocoacervate material. 
     
     
         3 . The stent system of  claim 2  wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents. 
     
     
         4 . The stent system of  claim 1  wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin. 
     
     
         5 . The stent system of  claim 1  wherein the biocompatible solvent is water. 
     
     
         6 . The stent system of  claim 1  further comprising one or more pharmacologically active agents. 
     
     
         7 . The stent system of  claim 6  wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol. 
     
     
         8 . A single strand stent system comprising a single strand twisted to form a loop strut or two or more rounded loops said loop strut or loops coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents. 
     
     
         9 . The single strand stent system of  claim 8  wherein the protein based material is a protein matrix material or a biocoacervate material. 
     
     
         10 . The single strand stent system of  claim 9  wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents. 
     
     
         11 . The single strand stent system of  claim 8  wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin. 
     
     
         12 . The single strand stent system of  claim 8  wherein the biocompatible solvent is water. 
     
     
         13 . The single strand stent system of  claim 8  further comprising one or more pharmacologically active agents. 
     
     
         14 . The single strand stent system of  claim 13  wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol. 
     
     
         15 . The single strand stent system of  claim 8  further comprising a mesh tube coated or encapsulated with the protein based material. 
     
     
         16 . The single strand stent system of  claim 8  includes the two or more loops and the loops are selected from the group consisting of o-rings, c-rings and oval-rings. 
     
     
         17 . A graft fastener comprising two or more clamping devices adjoined by a linking member and coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents. 
     
     
         18 . The graft fastener of  claim 17  wherein the protein based material is a protein matrix material or a biocoacervate material. 
     
     
         19 . The graft fastener of  claim 18  wherein the graft fastener is coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents. 
     
     
         20 . The graft fastener of  claim 17  wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin. 
     
     
         21 . The graft fastener of  claim 17  wherein the biocompatible solvent is water. 
     
     
         22 . The graft fastener of  claim 17  further comprising one or more pharmacologically active agents. 
     
     
         23 . The graft fastener of  claim 22  wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol. 
     
     
         24 . The graft fastener of  claim 17  wherein the clamping devices are selected from the group consisting of o-rings, c-rings and oval-rings. 
     
     
         25 . The graft fastener of  claim 17  wherein the clamping devices are adjoined with a linking member. 
     
     
         26 . A method of repairing a damaged or diseased vessel comprising:
 providing a stent system including two or more metallic or polymeric stents that are fitted to be inserted into each other; and a protein based material coating or encapsulating the one or more of the metallic or polymeric stents, the protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents;   administering the stent system to a damaged or diseased vessel.   
     
     
         27 . The method of repairing a damaged or diseased vessel of  claim 26  wherein the protein based material is a protein matrix material or a biocoacervate material. 
     
     
         28 . The method of repairing a damaged or diseased vessel of  claim 27  wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents. 
     
     
         29 . The method of repairing a damaged or diseased vessel of  claim 26  wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin. 
     
     
         30 . The method of repairing a damaged or diseased vessel of  claim 26  wherein the biocompatible solvent is water. 
     
     
         31 . The method of repairing a damaged or diseased vessel of  claim 26  further comprising one or more pharmacologically active agents. 
     
     
         32 . The method of repairing a damaged or diseased vessel of  claim 26  wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol. 
     
     
         33 . A method of repairing a damaged or diseased vessel comprising:
 providing a single strand stent system comprising a single strand twisted to form a loop strut or two or more rounded loops said loop strut or loops coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents; and   administering the single strand stent system to a damaged or diseased vessel.   
     
     
         34 . The method of repairing a damaged or diseased vessel of  claim 33  wherein the protein based material is a protein matrix material or a biocoacervate material. 
     
     
         35 . The method of repairing a damaged or diseased vessel of  claim 34  wherein the one or more stents are coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents. 
     
     
         36 . The method of repairing a damaged or diseased vessel of  claim 33  wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin. 
     
     
         37 . The method of repairing a damaged or diseased vessel of  claim 33  wherein the biocompatible solvent is water. 
     
     
         38 . The method of repairing a damaged or diseased vessel of  claim 33  further comprising one or more pharmacologically active agents. 
     
     
         39 . The method of repairing a damaged or diseased vessel of  claim 38  wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol. 
     
     
         40 . The method of repairing a damaged or diseased vessel of  claim 33  further comprising a mesh tube coated or encapsulated with the protein based material. 
     
     
         41 . The method of repairing a damaged or diseased vessel of  claim 33  includes the two or more loops and the loops are selected from the group consisting of o-rings, c-rings and oval-rings. 
     
     
         42 . A method of securing a vessel graft, stent or stent system in a vessel comprising,
 positioning a vessel graft, stent or stent system in a vessel lumen;   placing a graft fastener over the outer surface of the vessel and securing in place the vessel graft stent, or stent system, wherein the graft fastener includes two or more clamping devices adjoined by a linking member and coated or encapsulated with a protein based material including one or more biocompatible protein materials combined with one or more biocompatible solvents.   
     
     
         43 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 42  wherein the protein based material is a protein matrix material or a biocoacervate material. 
     
     
         44 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 44  wherein the graft fastener is coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents. 
     
     
         45 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 42  wherein the protein based material comprises one or more proteins selected from the group consisting of elastin, collagen, albumin, keratin, fibronectin, silk, silk fibroin, actin, myosin, fibrinogen, thrombin, aprotinin, antithrombin III, elastinlike blocks, silklike blocks, collagenlike blocks, lamininlike blocks, fibronectinlike blocks and silklike, elastinlike blocks, collagen-heparin and collagen-chondroitin. 
     
     
         46 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 42  wherein the biocompatible solvent is water. 
     
     
         47 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 42  further comprising one or more pharmacologically active agents. 
     
     
         48 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 46  wherein the one or more pharmacologically active agents is paclitaxel, rapamycin or estradiol. 
     
     
         49 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 42  wherein the clamping devices are selected from the group consisting of o-rings, c-rings and oval-rings. 
     
     
         50 . The method of securing a vessel graft, stent or stent system in a vessel of  claim 42  wherein the clamping devices are adjoined with a linking member.