Method of treating immune disease using b-cell antibodies

Abstract

Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to said tissue or organ, with an composition comprising antibody/fragment which specifically binds to targeted organ, tissue or cell. The antibody/fragment may be administered alone, or labeled or conjugated with an imaging, therapeutic, cytoprotective or activating agent.

1 . A method of ablating a targeted non-malignant B cell, comprising:
 administering to a human subject having an immune disease an unconjugated monoclonal antibody or antibody fragment which binds to a marker that is specific for a B cell, wherein the monoclonal antibody or antibody fragment binds specifically to the marker on the B cell,   thereby ablating the targeted non-malignant B cell to treat an immune disease associated with the targeted non-malignant B cell.   
     
     
         2 . The method according to  claim 1 , wherein the monoclonal antibody or antibody fragment binds to a marker that is specific for a normal B cell. 
     
     
         3 . The method according to  claim 1 , wherein the targeted non-malignant B cells are ectopic normal B cells. 
     
     
         4 . The method according to  claim 1 , wherein the unconjugated monoclonal antibody or antibody fragment is directed against normal and malignant B-cells. 
     
     
         5 . A method of ablating a targeted non-malignant B cell, consisting of:
 administering to a human subject an unconjugated monoclonal antibody or antibody fragment which binds to a marker that is specific for a B-cell,   wherein the monoclonal antibody or antibody fragment binds specifically to the marker on the B cell, thereby ablating the targeted non-malignant B cell to treat an immune disease associated with the targeted non-malignant B cell.   
     
     
         6 . A method of ablating a targeted ectopic non-malignant B cell, comprising:
 administering to a human subject an unconjugated monoclonal antibody or antibody fragment which binds to a marker that is specific for a B cell, wherein the monoclonal antibody or antibody fragment binds specifically to the marker on the B cell,   thereby ablating the targeted ectopic non-malignant B cell and treating a disease associated with the targeted ectopic non-malignant B cell.   
     
     
         7 . A method according to  claim 6 , wherein the disease is an immune disease. 
     
     
         8 . A method of ablating a targeted ectopic non-malignant B cell, comprising:
 administering to a human subject having an immune disease an unconjugated monoclonal antibody which binds to a marker that is specific for a B cell, wherein the monoclonal antibody binds specifically to the marker on the B cell, and   ablating the targeted ectopic non-malignant B cell, and   treating an immune disease associated with the targeted ectopic non-malignant B cell.