14189, a novel human kinase and uses thereof

Abstract

A novel human kinase protein and nucleic acid molecule are disclosed. In addition to the isolated kinase protein, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

1 . An isolated polypeptide comprising amino acid residues 13-304 of SEQ ID NO:2. 
     
     
         2 . The isolated polypeptide of  claim 1  which comprises the amino acid sequence SEQ ID NO:2. 
     
     
         3 . The isolated polypeptide of  claim 1  further comprising a non-kinase polypeptide. 
     
     
         4 . The isolated polypeptide of  claim 2  further comprising a non-kinase polypeptide. 
     
     
         5 . The isolated polypeptide of  claim 1  which comprises the amino acid sequence encoded by the cDNA insert of the plasmid deposited with ATCC as Accession Number PTA-2333. 
     
     
         6 . A composition comprising:
 an isolated polypeptide comprising amino acid residues 13-304 of SEQ ID NO:2; and   a pharmaceutically acceptable carrier.   
     
     
         7 . The composition of  claim 6  wherein the isolated polypeptide comprises the amino acid sequence SEQ ID NO:2. 
     
     
         8 . The composition of  claim 6  wherein the isolated polypeptide comprises the amino acid sequence encoded by the cDNA insert of the plasmid deposited with ATCC as Accession Number PTA-2333. 
     
     
         9 . The composition of  claim 6  which is sterile.