US2011105727A1PendingUtilityA1
Method for the humanization of antibodies and humanized antibodies thereby obtained
Est. expiryDec 24, 2023(expired)· nominal 20-yr term from priority
A61P 31/18A61P 35/00A61P 29/00A61P 25/04A61P 13/08A61P 1/18C07K 2317/24C07K 2317/565C07K 16/2863C07K 16/22C07K 2317/76A61K 2039/505C07K 2299/00C12N 15/85C07K 16/465G16B 15/00
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Claims
Abstract
Method for the humanization of the VII and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
Claims
exact text as granted — not AI-modified1 . A humanized anti-TrkA antibody comprising a VH region having the amino acid sequence set forth in SEQ ID No. 37, and a VL region having the amino acid sequence set forth in SEQ ID No. 38, or a fragment thereof which maintains TrkA binding activity.
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