Compositions for use in treating or preventing metabolic stress-induced lung injury and methods for increasing physical capacity of mammalian livestock

Abstract

The present invention relates to a composition comprising (i) choline and (ii) a compound selected from the group consisting of palmitate, vitamin C and vitamin E for use in treating or preventing metabolic stress-induced lung injury and a method for increasing physical capacity of mammalian livestock comprising administering to the mammalian livestock the above composition.

1 . A method of treating or preventing metabolic stress-induced lung injury, the method comprising administering to a subject a composition comprising
 choline and   a compound selected from the group consisting of palmitate, vitamin C and vitamin E wherein the metabolic stress-induced lung injury is acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) and/or exercise-induced pulmonary hemorrhage (EIPH).   
     
     
         2 . The method of  claim 1 , wherein the composition comprises choline and palmitate. 
     
     
         3 . The method of  claim 2 , wherein the composition further comprises (i) vitamin C, (ii) vitamin E or (iii) a combination of (i) and (ii). 
     
     
         4 . The method of  claim 1 , wherein choline is present in an amount of 1 to 30 mg/kg body weight (BW), preferably 3 to 25 mg/kg BW, even more preferred 5 to 15 mg/kg BW of free base. 
     
     
         5 . The method of  claim 1 , wherein palmitate is present in an amount of from 40 to 2000 mg/kg BW. 
     
     
         6 . The method of  claim 1 , wherein the metabolic stress-induced lung injury is trauma-induced lung injury or exercise-induced lung injury. 
     
     
         7 . The method of  claim 1 , wherein the compounds defined in  claims 1  are the only pharmaceutically active compounds for use in treating or preventing trauma-induced lung injury. 
     
     
         8 . A method for increasing physical capacity of mammalian livestock comprising feeding to the mammalian livestock a supplement comprising
 choline and   a compound selected from the group consisting of palmitate, vitamin C and vitamin E.   
     
     
         9 . The method of  claim 8 , wherein the supplement comprises choline and palmitate. 
     
     
         10 . The method of  claim 9 , wherein the supplement further comprises (i) vitamin C, (ii) vitamin E or (iii) a combination of (i) and (ii). 
     
     
         11 . The method of  claim 8 , wherein choline is present in an amount of 1 to 30 mg/kg BW of free base. 
     
     
         12 . The method of  claim 8 , wherein the mammalian livestock is selected from the group consisting of horse, camel, dog, cattle, and donkey, preferably horse, especially a racehorse. 
     
     
         13 . The method of  claim 8 , wherein the mammalian livestock is an animal used in animal racing. 
     
     
         14 . The method of  claim 8 , wherein increased physical capacity is increased duration of physical capacity, particularly duration of exercise; or reduced duration of recovery. 
     
     
         15 . The method of  claim 1 , wherein vitamin C is present in an amount of from 1 to 100 mg/kg. BW. 
     
     
         16 . The method of  claim 1 , vitamin E is present in an amount of from 0.05 to 10 mg/kg BW. 
     
     
         17 . The method of  claim 8 , wherein palmitate is present in an amount of from 40 to 2000 mg/kg BW. 
     
     
         18 . The method of  claim 8 , wherein vitamin C is present in an amount of from 1 to 100 mg/kg BW. 
     
     
         19 . The method of  claim 8 , wherein Vitamin E is present in an amount of from 0.05 to 10 mg/kg BW.