Combination neisserial compositions

Abstract

Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.

1 : An immunogenic composition comprising a first substantially purified polypeptide comprising a first amino acid sequence selected from (i) SEQ ID NO: 3518; (ii) a sequence having at least 90% sequence identity to SEQ ID NO: 3518; and (iii) a fragment of 8 or more contiguous amino acids from SEQ ID NO: 3518; and a second substantially purified polypeptide comprising a second amino acid sequence selected from (a) SEQ ID NO: 3926; (b) a sequence having at least 90% sequence identity to SEQ ID NO: 3926; and (c) a fragment of 8 or more contiguous amino acids from SEQ ID NO: 3926. 
     
     
         2 . The immunogenic composition of  claim 1  wherein the first amino acid sequence selected from (i) SEQ ID NO: 3518; (ii) a sequence having at least 95% sequence identity to SEQ ID NO: 3518; and (iii) a fragment of 14 or more contiguous amino acids from SEQ ID NO: 3518; and a second substantially purified polypeptide comprising a second amino acid sequence selected from (a) SEQ ID NO: 3926; (b) a sequence having at least 95% sequence identity to SEQ ID NO: 3926; and (c) a fragment of 14 or more contiguous amino acids from SEQ ID NO: 3926. 
     
     
         3 . The immunogenic composition of  claim 1  wherein the first amino acid sequence selected from (i) SEQ ID NO: 3518; and (ii) a fragment of 20 or more contiguous amino acids from SEQ ID NO: 3518; and a second substantially purified polypeptide comprising a second amino acid sequence selected from (a) SEQ ID NO: 3926; and (b) a fragment of 20 or more contiguous amino acids from SEQ ID NO: 3926.