Skin substitute membrane, mold, and method of evaluating external preparation for skin

Abstract

A skin substitute membrane includes a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter shape, the surface having an arithmetic mean roughness Sa of more than or equal to 10 μm to less than or equal to 50 μm. The depressed portion has a width of more than or equal to 50 μm to less than or equal to 500 μm and a depth of more than or equal to 30 μm to less than or equal to 150 μm. A spectral transmittance for light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength is more than or equal to 50% and less than or equal to 100%.

1 . A polymethylmethacrylate skin substitute membrane having a thickness of more than or equal to 0.2 mm and less than or equal to 5 mm and a spectral transmittance of more than or equal to 50% and less than or equal to 100% for light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength, comprising:
 a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter shape for increasing the spectral transmittance for the light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength, the surface having an arithmetic mean roughness Sa of more than or equal to 10 μm to less than or equal to 50 μm,   wherein the depressed portion has a width of more than or equal to 50 μm to less than or equal to 500 μm and a depth of more than or equal to 30 μm to less than or equal to 150 μm, and   the planar portion is provided with chamfered roughness for increasing the spectral transmittance for the light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength, and has an arithmetic mean roughness Sa of more than or equal to 0.1 μm to less than or equal to 30 μm.   
     
     
         2 - 6 . (canceled) 
     
     
         7 . A method of evaluating an external preparation for skin, comprising the steps of:
 applying the external preparation for skin on the skin substitute membrane as claimed in  claim 1 ; and   measuring an ultraviolet radiation transmission characteristic and/or reflection characteristic of the external preparation for skin by exposing the skin substitute membrane having the external preparation for skin applied thereon to light containing ultraviolet radiation.   
     
     
         8 . The method of evaluating the external preparation for skin as claimed in  claim 7 , wherein the ultraviolet radiation transmission characteristic and/or reflection characteristic is measured using at least one selected from the group consisting of an in vitro SPF evaluation method, an in vitro UVA evaluation method, an in vitro PPD method, an in vitro PFA method, an in vitro UVA PF method, a critical wavelength method, a UVA/UVB ratio method, an Australian/New Zealand method, a German DIN UVA balance method, and an SPF/UVA PF (PPD) ratio method. 
     
     
         9 . The method of evaluating the external preparation for skin as claimed in  claim 7 , wherein an amount of application of the external preparation for skin is more than or equal to 1.20 mg/cm 2  and less than or equal to 2.40 mg/cm 2 . 
     
     
         10 . The method of evaluating the external preparation for skin as claimed in  claim 8 , wherein an amount of application of the external preparation for skin is more than or equal to 1.20 mg/cm 2  and less than or equal to 2.40 mg/cm 2 .