US2011097425A1PendingUtilityA1

Methods of Treating Epiphora

33
Individually held — no corporate assignee on recordPriority: Nov 2, 2006Filed: Jan 7, 2011Published: Apr 28, 2011
Est. expiryNov 2, 2026(~0.3 yrs left)· nominal 20-yr term from priority
Inventors:Mitchell FriedlaenderHarun Takruri
A61P 27/02A61K 36/00A61K 36/53A61P 27/00
33
PatentIndex Score
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Claims

Abstract

The present invention is related to a method for treating epiphora, the method comprising administering to a nasal area of a subject in need thereof a composition comprising camphor, eucalyptus oil, and menthol, wherein the composition is substantially free of lipids other than the eucalyptus oil.

Claims

exact text as granted — not AI-modified
1 . A method for treating epiphora in a subject in need of such treatment, the method comprising administering to a nasal area of the subject a therapeutically effective amount of a composition comprising camphor,  eucalyptus  oil, and menthol, wherein the composition is substantially free of lipids other than the  eucalyptus  oil. 
     
     
         2 . The method of  claim 1 , wherein the composition is a gel, cream, ointment, jelly, lotion, or viscous liquid. 
     
     
         3 . The method of  claim 1 , wherein the composition further comprises a viscosity modifying agent. 
     
     
         4 . The method of  claim 3 , wherein the viscosity modifying agent is selected from the group consisting of polyethylene glycol, polyvinyl alcohol, gelatin, hyaluronic acid, carbomer, tragacanth, soluble cellulose derivatives, colloidal magnesium aluminum silicate, sodium alginate, and combinations thereof. 
     
     
         5 . The method of  claim 4 , wherein the viscosity modifying agent is polyethylene glycol. 
     
     
         6 . The method of  claim 4 , wherein the viscosity modifying agent is about 50% to about 95% (w/w) of the composition. 
     
     
         7 . The method of  claim 1 , wherein the camphor is about 1% to about 10% (w/w) of the composition. 
     
     
         8 . The method of  claim 1 , wherein the  eucalyptus  oil is about 0.5% to about 5% (w/w) of the composition. 
     
     
         9 . The method of  claim 1 , wherein the menthol is about 1% to about 10% (w/w) of the composition. 
     
     
         10 . The method of  claim 1 , wherein the composition is water soluble. 
     
     
         11 . The method of  claim 1 , wherein the composition further comprises an excipient. 
     
     
         12 . (canceled) 
     
     
         13 . The method of  claim 12 , wherein the excipient is about 0.05% to about 5% (w/w) of the composition. 
     
     
         14 . (canceled) 
     
     
         15 . The method of  claim 1 , wherein the composition further comprises a mucoadhesive. 
     
     
         16 . The method of  claim 15 , wherein the mucoadhesive is selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxy ethylcellulose, ethylcellulose, carboxymethyl cellulose, dextran, guar gum, polyvinyl pyrrolidone, a pectin, a starch, gelatin, casein, an acrylic acid polymer, a polymer of acrylic acid ester, an acrylic acid copolymer, a vinyl polymer, a vinyl copolymer, a polymer of vinyl alcohol, an alkoxy polymer, a polyethylene oxide polymer, a polyether, and combinations thereof. 
     
     
         17 . The method of  claim 1 , wherein said administering to a nasal area comprises administering to a nasal cavity, external nare, upper lip, philtrum, or combination thereof of the subject in need of such treatment. 
     
     
         18 . A method of treating epiphora in a subject in need of such treatment, the method comprising administering to an ocular area of the subject a therapeutically effective amount of a composition comprising camphor,  eucalyptus  oil, and menthol, wherein the composition is substantially free of lipids other than the  eucalyptus  oil. 
     
     
         19 . The method of  claim 18 , wherein the composition comprises (a) about 0.004% to about 0.4% (w/v) camphor; (b) about 0.001% to about 0.5% (w/v)  eucalyptus  oil; and (c) about 0.001% to about 0.5% (w/w) menthol. 
     
     
         20 . (canceled) 
     
     
         21 . The method of  claim 1 , wherein said composition comprises:
 (a) about 1.0% to about 10% (w/w) camphor;   (b) about 0.05% to about 5% (w/w)  eucalyptus  oil; and   (c) about 1.0% to about 10% (w/w) menthol.   
     
     
         22 . A composition comprising:
 (a) about 1.0% to about 10% (w/w) camphor;   (b) about 0.05% to about 5% (w/w)  eucalyptus  oil;   (c) about 1.0% to about 10% (w/w) menthol; and   (d) about 75% to about 97.5% (w/w) polyethylene glycol,   wherein the composition is substantially free of lipids other than the  eucalyptus  oil.   
     
     
         23 . (canceled) 
     
     
         24 . (canceled) 
     
     
         25 . (canceled) 
     
     
         26 . The method of  claim 1 , wherein the epiphora is brought about or exacerbated by irritation of the eye.

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