Novel alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Abstract

This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

1 . A piperidine derivative of the Formula I: 
       
         
           
           
               
               
           
         
         any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein 
         R a  represents hydrogen; 
         X represents —NR c —;
 wherein R c  represents hydrogen or alkyl; 
 
         R b  represents a naphthyl group,
 which naphthyl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, and alkoxy; 
 
         each of R 2 , R 2′ , R 6  and R 6′  represent alkyl; and 
         each of R 3 , R 3′ , R 5  and R 5′  represent hydrogen. 
       
     
     
         2 . The chemical compound of  claim 1 , any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof which is (1-Naphthoxy-phenyl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine. 
     
     
         3 . A pharmaceutical composition, comprising a therapeutically effective amount of a compound of  claim 1 , any of its stereoisomers or any mixture of its stereo-isomers, or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carrier, excipient or diluent.