Composition comprising iscom particles and live micro-organisms

Abstract

Iscom particles can be used as an adjuvant for preparing of an antigenic composition which comprises live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A composition may comprise at least one iscom particle and one or more live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A kit can comprise at least one compartment containing at least one living organism and at least one compartment containing at least one iscom particle.

1 - 17 . (canceled) 
     
     
         18 . A kit of parts comprising:
 at least one compartment comprising at least one living micro-organism; and   at least one compartment comprising at least one iscom particle.   
     
     
         19 . The kit according to  claim 18 , further comprising at least one killed or inactivated micro-organism, which may be present in a further compartment or in the same compartment as the at least one compartment comprising the at least one iscom particle. 
     
     
         20 . The kit according to  claim 18  or  19 , wherein the kit further comprises one or more antigenic molecules. 
     
     
         21 . The kit according to  claim 18  or  19 , wherein the iscom particle is an iscom comprising at least one glycoside, at least one lipid, and at least one hydrophobic protein or peptide-containing antigen. 
     
     
         22 . The kit according to  claim 21 , wherein the iscom particle comprises at least one glycoside fragment from  Quillaja Saponaria  Molina. 
     
     
         23 . The kit according to  claim 22 , wherein the iscom particle comprises Fraction A and/or Fraction C of Quil A of  Quillaja Saponaria  Molina. 
     
     
         24 . The kit according to  claim 18  or  19 , wherein the iscom particle is an iscom-matrix, comprising at least one glycoside and at least one lipid. 
     
     
         25 . The kit according to  claim 24 , wherein the iscom particle comprises at least one glycoside fragment from  Quillaja Saponaria  Molina. 
     
     
         26 . The kit according to  claim 25 , wherein the iscom particle comprises Fraction A and/or Fraction C of Quil A of  Quillaja Saponaria  Molina. 
     
     
         27 . The kit according to  claim 18  or  19 , wherein the living micro-organism is a virus. 
     
     
         28 . The kit according to  claim 18  or  19 , further comprising a pharmaceutically acceptable carrier, diluent, excipient, or additive. 
     
     
         29 . The kit according to  claims 18  or  19 , wherein the kit has components that are used in a method of preparing an antigenic composition comprising at least one iscom particle and at least one living micro-organism. 
     
     
         30 . A method of use of the kit according to  claim 18  comprising:
 mixing the at least one living micro-organism and the at least one iscom particle in a single composition; and 
 administering the single composition to a host. 
 
     
     
         31 . A method of use of the kit according to  claim 18  comprising co-administering to a host at the same event the at least one living micro-organism and the at least one iscom particle. 
     
     
         32 . The method according to  claims 30  or  31 , wherein the host is a human. 
     
     
         33 . A method of use of the kit according to  claim 19  comprising:
 mixing the at least one living micro-organism, the at least one iscom particle, and the at least one killed or inactivated micro-organism in a single composition; and 
 administering the single composition to a host. 
 
     
     
         34 . A method of use of the kit according to  claim 19  comprising co-administering to a host at the same event the at least one living micro-organism, the at least one iscom particle, and the at least one killed or inactivated micro-organism. 
     
     
         35 . The method according to  claim 33  or  34 , wherein the host is a human.