Bmp-1 procollagen c-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders

Abstract

Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.

1 . A method for diagnosing acute pancreatitis in an individual comprising: testing a blood sample from an individual to determine the presence in the sample of the BMP-1 isoform BMP-1-7, wherein the presence of said BMP-1 isoform in circulating blood of said individual is indicative of acute pancreatitis in the individual. 
     
     
         2 . A method for diagnosing chronic renal failure in an individual comprising: testing a blood sample from an individual to determine the presence in the sample of BMP-1 isoforms BMP-1-3 and BMP-1-5, wherein the presence of both said BMP-1 isoforms in circulating blood of said individual is indicative of chronic renal failure in said individual. 
     
     
         3 . A method of treating ischemic acute renal failure in an individual comprising administering a BMP-1 isoform systemically to the individual after diagnosis of renal injury. 
     
     
         4 . A method of treating ischemia/reperfusion damage to a kidney in an individual comprising: administering to the individual one or more antibody molecules specific for one or more BMP-1 isoforms in an amount effective to inhibit ischemia/reperfusion injury in said individual. 
     
     
         5 . The method according to  claim 4 , wherein the one or more antibody molecules to one or more BMP-1 isoforms is administered systemically to the individual prior to an ischemia/reperfusion event. 
     
     
         6 . The method according to  claim 4 , wherein an antibody molecule to BMP-1-1, an antibody molecule to BMP-1-3, or a combination of such antibody molecules is administered to the individual.