Vitamin-d-like compounds

Abstract

The present invention provides a compound represented by the following general formula (I): or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a compound, and the like. The compound or a pharmaceutically acceptable salt thereof, the pharmaceutical composition containing such a compound, or the like is useful as a medicine or the like for therapy of benign prostatic hyperplasia, cancer, osteoporosis, psoriasis, secondary hyperparathyroidism, chronic glomerulonephritis, lupus nephritis and/or diabetic nephropathy and the like.

1 .- 34 . (canceled) 
     
     
         35 . A compound represented by the following general formula (II): 
       
         
           
           
               
               
           
         
       
       wherein
 R 1  and R 2  independently represent an optionally substituted C 1-6  haloalkyl group, an optionally substituted C 2-6  alkenyl group, an optionally substituted C 2-6  alkynyl group or an optionally substituted C 1-6  alkoxy group, or R 1  and R 2  are taken together to form an optionally substituted C 3-8  cycloalkyl group; 
 R 3 , R 4 , R 5  and R 6  independently represent a hydrogen atom, a halogen atom, an optionally substituted C 1-6  alkyl group, a C 1-6  haloalkyl group, an optionally substituted C 2-6 , alkenyl group, an optionally substituted C 2-6  alkynyl group or an optionally substituted C 1-6  alkoxy group; 
 R 21  and R 22  independently represent a hydrogen atom or an optionally substituted C 1-6  alkyl group, or R 21  and R 22  are taken together with oxygen atoms and a boron atom to which they belong to form a 4- to 12-membered dioxaborane ring optionally substituted with a C 1-6  alkyl group; and 
 R 23  is a hydroxyl group, an optionally substituted C 6-12  aryl group, an optionally substituted 3- to 12-membered heterocycle, an optionally substituted C 1-6  alkoxy group or a group represented by the following general formula (III): 
 
       
         
           
           
               
               
           
         
       
       wherein R 7 , R 8  and R 9  independently represent a hydrogen atom, an optionally protected hydroxyl group, an optionally substituted amino group, an optionally substituted carboxyl group, an optionally substituted C 1-10  alkyl group or a C 1-6  haloalkyl group, or anyone pair of (R 7  and R 8 ), (R 7  and R 9 ) and (R 8  and R 9 ) are taken together to form an optionally substituted C 3-10  cycloalkyl group, a carbonyl group, an optionally substituted 3- to 12-membered heterocycle or a C 3-7  lactone; X is a direct bond, methylene, ethylene, vinylene, ethynylene, —O—, —S—, —NH—, carbonyl, an optionally substituted C 6-12  aryl group or an optionally substituted 3- to 12-membered heterocycle; and
 a represents an integer of 0 to 3, or a chemically acceptable salt thereof. 
 
     
     
         36 . The compound according to claim  1 , wherein R 23  is a group represented by the general formula (III), or a chemically acceptable salt thereof.