Modulation of the integrin linked kinase signaling pathway to promote cardiac cell proliferation and self-renewal

Abstract

The invention relates to a process for identification, amplification and differentiation of cardiac stem cells by utilizing an ILK based protocol. The invention further relates to a process for post myocardial infarction (IVII) remodeling by way of the integrin linked kinase (ILK) signaling pathway. Still further, the invention relates to a process for affecting an ability to control and/or manipulate stem cell frequency, cellular fate, self-renewal, multilineage differentiation, and potential for oncogenesis in cardiac tissue derived from embryonic stem cells, fetal tissue or adult tissue comprising modulation of ILK signaling amplification whereby stem cell renewal and expansion results.

1 . (canceled) 
     
     
         2 . (canceled) 
     
     
         3 . A process for identification, amplification and differentiation of cardiac stem cells by utilizing an ILK based protocol. 
     
     
         4 . A process for post myocardial infarction (IVII) remodeling by way of the integrin linked kinase (ILK) signaling pathway. 
     
     
         5 . The process of  claim 4  which further includes illiciting an overexpression of ILK. 
     
     
         6 . A process for affecting an ability to control and/or manipulate stem cell frequency, cellular fate, self-renewal, multilineage differentiation, and potential for oncogenesis in cardiac tissue derived from embryonic stem cells, fetal tissue or adult tissue comprising modulation of ILK signaling amplification whereby stem cell renewal and expansion results. 
     
     
         7 . The method of  claim 3 , further including incorporation of a supportive treatment strategy utilizing an anti-oxidant. 
     
     
         8 . The process of  claim 3 , wherein primary or secondary cardiospheres are utilized or produced. 
     
     
         9 . The method of  claim 4 , further including incorporation of a supportive treatment strategy utilizing an anti-oxidant. 
     
     
         10 . The process of  claim 4 , wherein primary or secondary cardiospheres are utilized or produced.