Combination Comprising Combretastatin and Anticancer Agents

Abstract

This invention relates to therapeutic combinations comprising VEGF Trap and a stilbene derivative, and to methods for treatment of cancer comprising administration of such combinations.

1 . A pharmaceutical composition comprising a pharmaceutically effective amount of VEGF Trap and a pharmaceutically effective amount of a stilbene derivative selected from the group consisting of 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         2 . A pharmaceutical composition according to  claim 1  wherein the stilbene derivative is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         3 . A pharmaceutical composition according to  claim 1  wherein the stilbene derivative is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         4 . A pharmaceutical composition according to  claim 1  wherein the stilbene derivative is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         5 . A pharmaceutical composition according to  claim 4  wherein the stilbene derivative is in the form of a hydrochloride salt. 
     
     
         6 . A method for the treatment of cancer comprising administration to a patient in need of such treatment, a pharmaceutically effective amount of a composition according to  claim 1 . 
     
     
         7 . A method for the treatment of cancer comprising administration to a patient in need of such treatment, a pharmaceutically effective amount of a composition according to  claim 2 . 
     
     
         8 . A method for the treatment of cancer comprising administration to a patient in need of such treatment, a pharmaceutically effective amount of a composition according to  claim 3 . 
     
     
         9 . A method for the treatment of cancer comprising administering to a patient in need of such treatment, a pharmaceutically effective amount of a composition according to  claim 4 . 
     
     
         10 . A method for the treatment of cancer, in a patient in need of such treatment, comprising administering to such patient a pharmaceutically effective amount of a combination of VEGF Trap and a stilbene derivative selected from the group consisting of 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         11 . A method according to  claim 10  wherein the stilbene derivative is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         12 . A method according to  claim 10  wherein the stilbene derivative is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         13 . A method according to  claim 10  wherein the stilbene derivative is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt of such stilbene derivative. 
     
     
         14 . A method according to  claim 10  wherein the VEGF Trap and stilbene derivative are administered separately. 
     
     
         15 . A method according to  claim 11  wherein the VEGF Trap and stilbene derivative are administered separately. 
     
     
         16 . A method according to  claim 12  wherein the VEGF Trap and stilbene derivative are administered separately. 
     
     
         17 . A method according to  claim 13  wherein the VEGF Trap and stilbene derivative are administered separately. 
     
     
         18 . A method according to  claim 10  wherein the VEGF Trap and stilbene derivative are administered simultaneously. 
     
     
         19 . A method according to  claim 11  wherein the VEGF Trap and stilbene derivative are administered simultaneously. 
     
     
         20 . A method according to  claim 12  wherein the VEGF Trap and stilbene derivative are administered simultaneously. 
     
     
         21 . A method according to  claim 13  wherein the VEGF Trap and stilbene derivative are administered simultaneously. 
     
     
         22 . A method according to  claim 10  wherein the VEGF Trap and stilbene derivative are administered semi-simultaneously. 
     
     
         23 . A method according to  claim 11  wherein the VEGF Trap and stilbene derivative are administered semi-simultaneously. 
     
     
         24 . A method according to  claim 12  wherein the VEGF Trap and stilbene derivative are administered semi-simultaneously. 
     
     
         25 . A method according to  claim 13  wherein the VEGF Trap and stilbene derivative are administered semi-simultaneously. 
     
     
         26 . A method according to  claim 13  wherein the stilbene derivative is in the form of a hydrochloride salt. 
     
     
         27 . A method according to  claim 17  wherein the stilbene derivative is in the form of a hydrochloride salt. 
     
     
         28 . A method according to  claim 21  wherein the stilbene derivative is in the form of a hydrochloride salt. 
     
     
         29 . A method according to  claim 25  wherein the stilbene derivative is in the form of a hydrochloride salt.