Coated medical implants

Abstract

Coated medical devices are disclosed. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats. In certain embodiments of the invention, a medical device is coated on at least a portion of its surface with a first coating comprising a therapeutic agent and a wax or fat. The coated medical device may be a stent or catheter.

1 .- 67 . (canceled) 
     
     
         68 . A medical device coated on at least a portion of its surface with a first coating comprising a therapeutic agent and a wax or fat. 
     
     
         69 . A medical device as in  claim 68  wherein said first coating has a thickness of about 1 to 30 microns. 
     
     
         70 . A medical device as in  claim 68  wherein said first coating is one layer or multiple layers of the same or different coating materials. 
     
     
         71 . A medical device as in  claim 68  wherein the medical device comprises a substrate formed of metal, polymer, ceramic, composite or combinations thereof. 
     
     
         72 . A medical device as in  claim 68  wherein the medical device is selected from the group consisting of catheters, needle injection catheters, blood clot filters, vascular grafts, stent grafts, biliary stents, colonic stents, bronchial/pulmonary stents, esophageal stents, ureteral stents, aneurysm filling coils, other coiled coil devices, trans myocardial revascularization devices, and percutaneous myocardial revascularization devices. 
     
     
         73 . A medical device as in  claim 68  claim wherein the medical device is a stent. 
     
     
         74 . A medical device as in  claim 68  wherein the therapeutic agent comprises an anti-angiogenic agent. 
     
     
         75 . A medical device as in  claim 68  wherein the therapeutic agent comprises an agent blocking smooth muscle cell proliferation. 
     
     
         76 . A medical device as in  claim 68  wherein the therapeutic agent is a member of the group consisting of rapamycin, angiopeptin, and monoclonal antibodies capable of blocking smooth muscle cell proliferation. 
     
     
         77 . A medical device as in  claim 68  wherein the therapeutic agent is rapamycin. 
     
     
         78 . A medical device as in  claim 68  wherein the therapeutic agent comprises an antineoplastic/antiproliferative/anti-mitotic agent. 
     
     
         79 . A medical device as in  claim 68  wherein the therapeutic agent is a member of the group consisting of paclitaxel, 5-fluorouracil, methotrexate, doxorubicin, daunorubicin, cyclosporine, cisplatin, vinblastine, vincristine, colchicine, epothilones, endostatin, angiostatin, Squalamine, and thymidine kinase inhibitors. 
     
     
         80 . A medical device as in  claim 68  wherein the therapeutic agent is paclitaxel. 
     
     
         81 . A medical device as in  claim 68  wherein the coating comprises a fat. 
     
     
         82 . A medical device as in  claim 68  wherein the coating comprises a wax. 
     
     
         83 . A medical device as in  claim 68  wherein the medical device is a catheter. 
     
     
         84 . A stent having a coating thereon, the coating comprising a therapeutic agent and a wax or fat. 
     
     
         85 . A stent as in  claim 84  wherein said stent is a vascular stent, a biliary stent, a colonic stent, a bronchial/pulmonary stent, an esophageal stent or a ureteral stent. 
     
     
         86 . A stent as in  claim 84  wherein the coating comprises a fat. 
     
     
         87 . A vascular stent having a coating thereon, the coating comprising a fat.