Perfluoro sulfonyl halides and related species as polymer support modifiers

Abstract

Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula: wherein L is a linking group component; X is F, Cl, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided.

1 - 46 . (canceled) 
     
     
         47 . A linker reagent having the formula: 
       
         
           
           
               
               
           
         
         wherein
 L is a linking group component; and 
 A is an attaching group. 
 
       
     
     
         48 . A linker reagent of  claim 47 , wherein said attaching group is a member selected from the group consisting of NH 2 , NHR, CO 2 H, CO 2 R, COCl, OH, SH, and protected forms thereof, wherein each R is independently a member selected from the group consisting of substituted (C 1 -C 8 )alkyl, unsubstituted (C 1 -C 8 )alkyl, substituted aryl, and unsubstituted aryl. 
     
     
         49 . A linker reagent of  claim 47 , wherein said attaching group is CO 2 H. 
     
     
         50 . (canceled) 
     
     
         51 . A linker reagent of  claim 47 , wherein L is a member selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
       wherein
 Y is a member selected from the group consisting of a chemical bond, O, C(O), S, and NR 1 ; 
 Z is a member selected from the group consisting of a chemical bond and C(O); 
 R 1  is a member selected from the group consisting of H and (C 1 -C 8 )alkyl; 
 each R 2  is independently a member selected from the group consisting of hydrogen, halogen, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy, (C 2 -C 8 )heteroalkyl, (C 1 -C 8 )alkylthio, (C 1 -C 8 )alkylamino, di(C 1 -C 8 )alkylamino, cyano, nitro, and (C 1 -C 8 )alkylsulfonyl; 
 the subscript g is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; 
 the subscript i is an integer selected from the group consisting of 1, 2, 3, 4, 5, and 6; 
 the subscript j is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; 
 the subscript k is an integer selected from the group consisting of 1, 2, 3, and 4; 
 the subscript m is an integer selected from the group consisting of 2, and 3; and 
 the subscript n is an integer selected from the group consisting of 0, 1, 2, 3, and 4. 
 
     
     
         52 . A linker reagent in accordance with  claim 47 , having the formula:
   HO 2 C—(CH 2 ) j —(CF 2 CF 2 ) k O—(CF 2 ) 2 —SO 2 F
   wherein   the subscript j is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10; and   the subscript k is an integer selected from the group consisting of 1, 2, 3, and 4.   
     
     
         53 . A linker reagent in accordance with  claim 47 , wherein the subscript j is 1 and the subscript k is 1. 
     
     
         54 . A linker reagent in accordance with  claim 47 , having the formula:
   HO 2 C—(CH 2 ) g —(CF 2 ) i —SO 2 F
   wherein the subscript g is an integer selected from the group consisting of 3, 4, 5, and 6; and   the subscript i is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10.