US2011021755A1PendingUtilityA1
Optimized Fc Variants
Est. expiryMar 3, 2023(expired)· nominal 20-yr term from priority
Inventors:Gregory Alan LazarWei DangJohn DesjarlaisSher Bahadur KarkiOmid VafaRobert HayesJost Vielmetter
A61P 43/00C07K 16/32C07K 16/2863C07K 16/00C07K 2317/92C07K 2317/41C07K 2317/94C07K 16/2896C07K 2317/77C07K 2317/72C07K 2317/71C07K 2317/52C07K 16/2893C07K 2317/24C07K 2317/732C07K 2317/34C07K 16/18C07K 16/30A61K 2039/505C07K 16/2887C07K 2317/64C07K 2317/734C07K 2317/40C07K 2317/56C07K 2317/31
60
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Claims
Abstract
The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
Claims
exact text as granted — not AI-modified1 . 1. An antibody or immunoadhesin comprising an Fc variant of parent Fc polypeptide, said Fc variant comprising an amino acid substitution in the Fc region selected from 267D and 267E, and wherein numbering is according to the EU index.
2 . A protein comprising an Fc variant of parent Fc polypeptide, said Fc variant comprising an amino acid substitution in the Fc region selected from 267D and 267E, and wherein numbering is according to the EU index.Join the waitlist — get patent alerts
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