US2011021591A1PendingUtilityA1

Phenylbutazone carrier formulation showing increased bioactivity in animals

62
Individually held — no corporate assignee on recordPriority: Jul 21, 2009Filed: Oct 29, 2009Published: Jan 27, 2011
Est. expiryJul 21, 2029(~3 yrs left)· nominal 20-yr term from priority
Inventors:Douglas J. Gordon
A61K 9/145A61P 29/00A61K 31/415A61K 9/143
62
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Claims

Abstract

An improved phenylbutazone carrier composition provides increased palatability to horses. Additionally, the composition improves the bioavailability of the phenylbutazone and thus increases the horse's blood plasma levels of the medicine for the same effective dosage of the medicine.

Claims

exact text as granted — not AI-modified
1 . A phenylbutazone composition comprising:
 phenylbutazone;   artificial flavor;   saccharine;   aspartame; and   sucralose.   
     
     
         2 . The composition of  claim 1 , wherein the composition comprises, as a percentage of the weight of phenylbutazone:
 about 2 percent flavoring;   about 3.5 percent saccharine;   about 1 percent aspartame;   about 2 percent sucralose.   
     
     
         3 . The composition of  claim 1 , further comprising sodium bicarbonate. 
     
     
         4 . The composition of  claim 3 , wherein the composition comprises, as a percentage of the weight of phenylbutazone, about 2 percent sodium bicarbonate. 
     
     
         5 . The composition of  claim 2 , wherein the composition further comprises, as a percentage of the weight of phenylbutazone, about 2 percent sodium bicarbonate. 
     
     
         6 . A phenylbutazone composition comprising:
 phenylbutazone;   artificial sweeteners; and   sodium bicarbonate.   
     
     
         7 . The composition of  claim 6 , wherein the composition comprises, as a percentage of the weight of phenylbutazone, about 2 percent of sodium bicarbonate. 
     
     
         8 . The composition of  claim 7 , wherein the composition comprises, as a percentage of the weight of phenylbutazone, about 4 percent saccharine and between about 1 and 2 percent aspartame. 
     
     
         9 . The composition of  claim 8 , wherein the composition further comprises, as a percentage of the weight of phenylbutazone, between about 2 and 4 percent sucralose. 
     
     
         10 . The composition of  claim 6 , further comprising artificial flavor. 
     
     
         11 . The composition of  claim 6 , further comprising an anti caking agent. 
     
     
         12 . The composition of  claim 6 , wherein the composition comprises, as a percentage of the weight of phenylbutazone:
 about 2 percent sodium bicarbonate;   about 4 percent saccharine;   between about 1 and 2 percent aspartame;   artificial flavoring; and   anti-caking agent.   
     
     
         13 . The composition of  claim 12 , wherein the composition further comprises, as a percentage of the weight of phenylbutazone, between about 2 and 4 percent sucralose. 
     
     
         14 . A phenylbutazone composition comprising:
 phenylbutazone; and, for each 100 grams of phenylbutazone further comprising:
 about 4 grams of saccharine; 
 between about 1 and 2 grams of aspartame; and 
 about 2 grams of sodium bicarbonate. 
   
     
     
         15 . The composition of  claim 14 , further comprising, for each 100 grams of phenylbutazone, between about 2 and 4 grams of flavoring. 
     
     
         16 . The composition of  claim 14 , further comprising, for each 100 grams of phenylbutazone, between about 2 and 4 grams of anti caking agent. 
     
     
         17 . The composition of  claim 14 , further comprising, for each 100 grams of phenylbutazone, between about 2 and 4 grams of sucralose. 
     
     
         18 . The composition of  claim 14 , wherein the composition is formulated as a powder. 
     
     
         19 . The composition of  claim 14 , wherein the composition is for delivery to animals.

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