Purified sr-p70 protein

Abstract

The invention relates to new nucleic acid sequences of the family of tumor-suppressing genes related to the gene for the p53 protein, and to corresponding protein sequences.

1 . A monoclonal or polyclonal antibody or their fragments, a chimeric antibody or an immunoconjugate capable of specifically recognizing a polypeptide comprising amino acid sequence SEQ ID NO:6. 
     
     
         2 . A method of purifying or detecting a polypeptide comprising amino acid sequence SEQ ID NO:6, the method comprising:
 a) contacting the antibody or the immunoconjugate of  claim 1  to a biological sample; and   b) purifying or detecting a polypeptide comprising amino acid sequence SEQ ID NO:6 bound by the antibody or the immunoconjugate of  claim 1 .   
     
     
         3 . A method of in vitro diagnosis of pathologies correlated with an expression or an abnormal accumulation of SR-p70 proteins from a biological sample, the method comprising:
 a) contacting the antibody or the immunoconjugate of  claim 1  to a biological sample; and   b) identifying specific immunological complexes between an SR-p70 protein and the antibody or the immunoconjugate of  claim 1     wherein an abnormal accumulation of SR-p70 proteins identifies a pathology associated with an abnormal accumulaton of SR-p70.   
     
     
         4 . A kit for the in vitro diagnosis of an expression or an abnormal accumulation of SR-p70 proteins in a biological sample or for measuring the level of expression of these proteins in the said sample, comprising:
 at least one antibody according to  claim 1 , optionally bound to a support,   means of visualization of the formation of specific antigen-antibody complexes between an SR-p70 protein and the said antibody, or means of quantification of these complexes.