Composition comprising a combination of an aromatase inhibitor, a progestin and an oestrogen and its use for the treatment of endometriosis

Abstract

The invention relates to a method of treating endometriosis using a combination of an aromatase inhibitor, a progestin and an oestrogen. The invention also relates to pharmaceutical formulations comprising said combination.

1 . The use of a combination of an aromatase inhibitor, a progestin and an oestrogen in the manufacture of a medicament for the treatment of endometriosis. 
     
     
         2 . The use according to  claim 1  wherein the aromatase inhibitor is selected from atamestane, formestane, fadrozole, letrozole, pentrozole, anastrozole and vorozole. 
     
     
         3 . The use according to  claim 2  wherein the aromatase inhibitor is anastrozole. 
     
     
         4 . The use according to any one of the preceding claims wherein the progestin is selected from norgestrel, levonorgestrel, norethindrone, norethindrone acetate, desogestrel, norgestimate and ethynodiol diacetate. 
     
     
         5 . The use according to  claim 4  wherein the progestin is levonogestrol. 
     
     
         6 . The use according to any one of the preceding claims wherein the oestrogen is selected from ethinyl oestradiol and mestranol. 
     
     
         7 . The use according to  claim 6  wherein the oestrogen is ethinyl oestradiol. 
     
     
         8 . A pharmaceutical composition comprising a combination according to any one of  claims 1  to  7 . 
     
     
         9 . A pharmaceutical composition according to  claim 8  for the treatment of endometriosis. 
     
     
         10 . A method of the treatment of endometriosis comprising the administration of a combination of an aromatase inhibitor, a progestin and an oestrogen.