US2011008420A1PendingUtilityA1
Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
Individually held — no corporate assignee on recordPriority: Oct 4, 1999Filed: Sep 10, 2010Published: Jan 13, 2011
Est. expiryOct 4, 2019(expired)· nominal 20-yr term from priority
Inventors:Hampar L. Karagoezian
A61P 31/00A61P 27/02A61P 31/10A61P 31/12A61P 27/04A61P 31/04A61K 33/14A61K 33/40A61K 9/0014A61K 33/00A61K 33/22A61L 12/10A61K 31/728A61P 17/06A61P 17/02A61L 12/124A61K 33/20A61P 17/00A01N 59/00A61K 9/0048
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Claims
Abstract
An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
Claims
exact text as granted — not AI-modified1 . An anti-microbial preservative for use in an ophthalmic product, the preservative comprising from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound, wherein the preservative does not generate chlorine dioxide, and wherein the preservative is at a pH range between about 6.0 and about 8.8.
2 . The preservative of claim 1 wherein the chlorite compound is a metal chlorite.
3 . The preservative of claim 2 wherein the metal is sodium.
4 . The preservative of claim 2 wherein the metal is selected from the group consisting of potassium, calcium, and magnesium.
5 . The preservative of claim 1 wherein the peroxy compound is hydrogen peroxide.
6 . The preservative of claim 1 wherein the ophthalmic product is an artificial tear solution.
7 . The preservative of claim 1 wherein the ophthalmic product is a contact lens disinfecting solution.
8 . The preservative of claim 1 wherein the ophthalmic product is a contact lens cleaning solution.
9 . The preservative of claim 8 wherein the cleaning solution is directly applied to a contact lens in place on an eye of a living being.
10 . An antimicrobial ophthalmic composition for direct application onto an eye of a living being, the composition comprising from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound, wherein the composition does not generate chlorine dioxide, and wherein the composition is at a pH range between about 6.0 and 8.8.
11 . The antimicrobial ophthalmic composition of claim 10 wherein the chlorite compound is a metal chlorite.
12 . The antimicrobial ophthalmic composition of claim 11 wherein the metal is sodium.
13 . The antimicrobial ophthalmic composition of claim 11 wherein the metal is selected from the group consisting of potassium, calcium, and magnesium.
14 . The antimicrobial ophthalmic composition of claim 10 wherein the peroxy compound is hydrogen peroxide.
15 . The antimicrobial ophthalmic composition of claim 10 additionally comprising a lubricant chosen from the group consisting of non-ionic polymeric lubricants, anionic polymeric lubricants, and combinations thereof.
16 . The antimicrobial ophthalmic composition of claim 15 additionally comprising a block polymer based surfactant.
17 . The antimicrobial ophthalmic composition of claim 15 wherein the ophthalmic composition additionally comprises:
lubricant
0.05 wt. % to 0.3 wt. %;
boric acid
0.15 wt. % to 0.3 wt. %;
sodium chloride
0.50 wt. % to 0.8 wt. %;
surfactant
0.05 wt. % to 0.3 wt. %;
HCl or NaOH
to adjust pH; and
purified water
Q.S. to volume.
18 . The antimicrobial ophthalmic composition of claim 17 additionally comprising from about 0.001 wt. % to about 0.50 wt. % of sodium hyaluronate.
19 . The antimicrobial ophthalmic composition of claim 15 wherein the ophthalmic composition additionally comprises:
lubricant
0.05 wt. % to 0.30 wt. %;
sodium phosphate monobasic
0.10 wt. % to 0.25 wt. %;
sodium phosphate dibasic
0.10 wt. % to 0.40 wt. %;
sodium chloride
0.50 wt. % to 0.80 wt. %;
surfactant
0.05 wt. % to 0.30 wt. %;
HCl or NaOH
to adjust pH; and
purified water
Q.S. to volume.
20 . The antimicrobial ophthalmic composition of claim 19 additionally comprising from about 0.001 wt. % to about 0.50 wt. % sodium hyaluronate.
21 . The antimicrobial ophthalmic composition of claim 10 wherein the composition is applied onto an eye for treating dryness of the eye.
22 . The antimicrobial ophthalmic composition of claim 10 wherein the composition is applied onto an eye for treating an infection of an eye.
23 . The antimicrobial ophthalmic composition of claim 22 wherein the infection is caused by bacterial keratitis.
24 . The antimicrobial ophthalmic composition of claim 22 wherein the infection is caused by a virus.
25 . The antimicrobial ophthalmic composition of claim 22 wherein the infection is caused by a fungus.
26 . The antimicrobial ophthalmic composition of claim 10 wherein the composition is applied onto an eye for cleansing a contact lens in place on the eye.
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56 . An antimicrobial preservative for use in a dermatology product, the preservative comprising from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound, wherein the preservative does not generate chlorine dioxide, and wherein the preservative is at a pH range between about 5.0 and about 8.8.
57 . The preservative of claim 55 wherein the chlorite compound is a metal chlorite.
58 . The preservative of claim 57 wherein the metal is sodium.
59 . The preservative of claim 57 wherein the metal is selected from the group consisting of potassium, calcium, and magnesium.
60 . The preservative of claim 55 wherein the peroxy compound is hydrogen peroxide.
61 . The preservative of claim 55 wherein the dermatology product is Decubitus gel or a cream.
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