US2011003972A1PendingUtilityA1
Stabilizing polypeptides which have been exposed to urea
Individually held — no corporate assignee on recordPriority: Dec 19, 2001Filed: Jun 21, 2010Published: Jan 6, 2011
Est. expiryDec 19, 2021(expired)· nominal 20-yr term from priority
A61P 43/00A61K 39/3955C07K 16/32C07K 16/2863C07K 2317/76A61K 39/39591A61K 47/18C07K 2317/24A61K 47/183C07K 16/065
51
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Claims
Abstract
Methods for stabilizing polypeptides, such as anti-HER2 antibodies, which have been exposed to urea.
Claims
exact text as granted — not AI-modified1 - 6 . (canceled)
7 . A process for preventing or inhibiting carbamylation of a polypeptide resulting from exposure to urea, comprising exposing the polypeptide to urea, or cyanate formed by decomposition of urea, in the presence of an amine containing solution.
8 . The process of claim 7 wherein said amine containing solution comprises a constituent comprising an amino acid.
9 . The process of claim 8 wherein the amino acid in the constituent is glycine.
10 . The process of any one of claims 7 to 9 wherein the amine in said amine containing solution functions as a cyanate scavenger.
11 . The process of claim 10 wherein the cyanate scavenger is present in an amount effective to prevent or inhibit carbamylation of the polypeptide.
12 . The process of claim 7 wherein the final concentration of the amine containing solution is from about 20 mM to about 1 M.
13 . The process of claim 7 wherein the final concentration of the amine containing solution is from about 200 mM to about 400 mM.Join the waitlist — get patent alerts
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