Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate

Abstract

The present invention relates to new polymorphs of S-(+)-Clopidogrel bisulfate and a process for preparing the same.

1 . Amorphous S-(+) Clopidogrel bisulfate having a powder X-ray diffraction pattern substantially as depicted in  FIG. 1 . 
     
     
         2 - 36 . (canceled) 
     
     
         37 . Amorphous S-(+) Clopidogrel bisulfate as claimed in  claim 1  in anhydrous form. 
     
     
         38 . Amorphous S-(+) Clopidogrel bisulfate as claimed in  claim 1  in hydrated form. 
     
     
         39 . A pharmaceutical composition comprising amorphous S-(+) Clopidogrel bisulfate as claimed in  claim 1 . 
     
     
         40 . A pharmaceutical dosage form comprising a pharmaceutical composition of amorphous S-(+) Clopidogrel bisulfate having a powder X-ray diffraction pattern substantially as depicted in  FIG. 1 . 
     
     
         41 . A method of treatment comprising administering a composition of amorphous S-(+) Clopidogrel bisulfate having a powder X-ray diffraction pattern substantially as depicted in  FIG. 1  in a therapeutically effective amount for the treatment of a cardiovascular disorder. 
     
     
         42 . The method as claimed in  claim 40 , wherein the amorphous S-(+) Clopidogrel bisulfate is in anhydrous form. 
     
     
         43 . The method as claimed in  claim 40 , wherein the amorphous S-(+) Clopidogrel bisulfate is in hydrated form.