Topical compositions for anti-aging and methods of using same

Abstract

A pharmaceutical composition for treatment of skin aging including a pharmaceutically effective amount of estriol; a pharmaceutically effective amount of estradiol; a pharmaceutically effective amount of hyaluronic acid; a pharmaceutically effective amount of green tea extract; and a pharmaceutically acceptable carrier is provided. In some embodiments, the composition further includes ascorbic acid, date palm extract, or a combination thereof. Also disclosed is a method for treating symptoms of skin aging and photoaging by administering a pharmaceutical composition having estriol, estradiol, hyaluronic acid, green tea extract, a pharmaceutically acceptable carrier and optionally, ascorbic acid and date palm extract. A method of promoting urogenital function is likewise provided wherein a pharmaceutical composition having estriol, estradiol, hyaluronic acid, and green tea extract is applied intravaginally.

1 . A method for promoting urogenital function to a person in need of such treatment, comprising:
 administering intravaginally to said individual a pharmaceutically effective dose of a composition, comprising:
 a pharmaceutically effective amount of estriol; 
 a pharmaceutically effective amount of estradiol; 
 a pharmaceutically effective amount of hyaluronic acid; 
 a pharmaceutically effective amount of green tea extract; and 
 a pharmaceutically acceptable carrier. 
   
     
     
         2 . The method of  claim 1 , wherein said pharmaceutically effective amount of estriol is between about 0.01 to about 3.0 w/w %. 
     
     
         3 . The method of  claim 1 , wherein said pharmaceutically effective amount of estradiol is between about 0.0001 to about 3.0 w/w %. 
     
     
         4 . The method of  claim 1 , wherein said pharmaceutically effective amount of hyaluronic acid is between about 0.01 to about 50.0 w/w %. 
     
     
         5 . The method of  claim 1 , wherein said pharmaceutically effective amount of green tea extract is between about 0.01 and 10.0 w/w %. 
     
     
         6 . The method of  claim 1 , wherein said estriol comprises between about 0.01 to about 3.0 w/w %, said estradiol comprises between about 0.0001 to 3.0 w/w %, said hyaluronic acid comprises between about 0.01 to about 50.0 w/w %; and said green tea extract comprises between about 0.01 to about 10.0 w/w %. 
     
     
         7 . The method of  claim 1 , wherein said pharmaceutically acceptable carrier is selected from the group consisting of a cream, an ointment, a lotion, a gel, a suppository, and a foam. 
     
     
         8 . The method of  claim 1 , wherein said person suffers from symptoms of urogenital dysfunction selected from the group consisting of incontinence, vulvar atrophy, vaginal atrophy, vaginal dryness, and pelvic floor weakness. 
     
     
         9 . The method of  claim 1 , wherein said composition further comprises a pharmaceutically effective amount of ascorbic acid, date palm extract, or a combination thereof 
     
     
         10 . The method of  claim 9 , wherein said effective amount of ascorbic acid is between about 0.01 and 10.0 w/w %. 
     
     
         11 . The method of  claim 9 , wherein said effective amount of date palm extract is between about 0.01 and 25.0 w/w %.