Foamable alcohol compositions, systems and methods of use

Abstract

A composition, systems for dispensing the composition and methods for the use of the composition are described. The composition comprises: (A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity; (B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.

1 . A non-aerosol foamable composition, comprising:
 (A) monohydric alcohol present in the composition at a concentration from about 35% to about 99.5% by weight;   (B) a dimethicone surfactant selected from the group consisting of hydroxy-terminated dimethicone copolyol, hydroxyl-capped dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, silicone copolyol pelargonate, Silicone Quaternary 1, Silicone Quaternary 2 (Myristyl), sodium dimethicone copolyol acetyl methyltaurate, dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol lactate, dimethicone copolyol adipate, dimethicone copolyolamine, dimethicone copolyol benzoate, dimethicone copolyol phthalate, dimethicone copolyol undecylenate, dimethicone copolyol crosspolymer, dimethicone copolyol lactate, dimethicone propyl pg-betaine, polysilicone-10, bis-hydroxyethoxypropyl dimethicone, disodium copolyol dimethicone sulfosuccinate, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, sodium carboxydecyl copolyol dimethicone; and combinations of two or more of the foregoing; and   (C) a component selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cetyl hydroxyethyl cellulose, ethylhydroxy ethyl cellulose, hydroxypropyl guar, polyglycerol, polyoxamer having a molecular weight of at least 100,000, polyoxamine, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-9, polyquaternium-11 to polyquaternium-47, polyvinyl methyl ether, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing;   wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 50 cps at 23° C.; and   wherein the foamable composition forms a foam that maintains a measurable height for at least 5 seconds following creation of the foam.   
     
     
         2 . The composition of  claim 1  which demonstrates a percentage foam volume increase of at least 100%. 
     
     
         3 . The composition of  claim 1  wherein the viscosity of the composition prior to foaming at 23° C. is within the range from about 0.5 cps to about 50 cps. 
     
     
         4 . The composition of  claim 1  wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 20 cps at 23° C. 
     
     
         5 . The composition of  claim 4  wherein the viscosity of the composition prior to foaming at 23° C. is within the range from about 0.5 cps to about 20 cps. 
     
     
         6 . The composition of  claim 1  wherein the foam is formed from the foamable composition without the use of a propellant when shaken or dispensed from a dispenser. 
     
     
         7 . The composition of  claim 1  wherein the component (C) is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl guar, ethylhydroxy ethyl cellulose, polyoxamer, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylic acid, polyquaternium-2, polyquaternium-4, polyquaternium-11, polyquaternium-15, polyquaternium-16, polyquaternium-22, polyquaternium-24, polyquaternium-28, polyquaternium-44, polyquaternium-46, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing. 
     
     
         8 . The composition of  claim 1  wherein the component (C) is a homopolymer or copolymer containing N-vinyl lactam monomeric units selected from the group consisting of N-vinyl-2-pyrrolidone, N-vinyl-2-valerolactam, N-vinyl-2-caprolactam, and mixtures of any of the foregoing, and optionally one or more comonomers selected from the group consisting of N,N-dimethylacrylamide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamido-2-methyl-1-propane sulfonic acid or its salt, vinyl acetate, and mixtures of any of the foregoing. 
     
     
         9 . The composition of  claim 1  wherein the component (C) is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, polyethylene-polypropylene copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose, and combinations of two or more of the foregoing. 
     
     
         10 . The composition of  claim 1  wherein the monohydric alcohol is selected from the group consisting of ethanol, propanol, butanol, and combinations of two or more of the foregoing. 
     
     
         11 . The composition of  claim 1  wherein the monohydric alcohol is present in the composition at a concentration from about 60% to about 80% by weight. 
     
     
         12 . The composition of  claim 1  wherein the surfactant is present in the composition at a concentration from about 0.1% to about 10% by weight. 
     
     
         13 . The composition of  claim 12  wherein the surfactant is present in the composition at a concentration from about 0.5% to about 5% by weight. 
     
     
         14 . The composition of  claim 1  wherein the component (C) is present in the composition at a concentration between about 0.001% and about 5% by weight. 
     
     
         15 . The composition of  claim 1  wherein the component (C) is present in the composition at a concentration less than or equal to about 0.5% by weight. 
     
     
         16 . The composition of  claim 15  wherein the component (C) is present in the composition at a concentration less than or equal to about 0.1% by weight. 
     
     
         17 . The composition of  claim 16  wherein the component (C) is present in the composition at a concentration of about 0.06% by weight. 
     
     
         18 . The composition of  claim 1  wherein the dimethicone surfactant is selected from hydroxy-terminated dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, or combination of two or more of the foregoing. 
     
     
         19 . The composition of  claim 1  further comprising an emollient wherein the emollient is present in the composition at a concentration of about 30% by weight or less. 
     
     
         20 . The composition of  claim 1  further comprising an antifungal agent. 
     
     
         21 . The composition of  claim 1  further comprising an antimicrobial agent, present in the composition at a concentration up to about 10% by weight. 
     
     
         22 . The composition of  claim 21  wherein the antimicrobial agent is selected from the group consisting of parachlorometaxylenol, triclosan, chlorhexidine and its salts, polyhexamethylene biguanide and its salts, iodine, idodophors, fatty acid monoesters, poly-n-vinyl pyrrolidone-iodophors, silver oxide, silver and its salts, peroxides, antibiotics, and combinations of two or more of the foregoing. 
     
     
         23 . The composition of  claim 22  wherein the antimicrobial agent is benzoyl peroxide. 
     
     
         24 . The composition of  claim 1  further comprising one or more skin barrier materials in an amount from about 0.1% to 60% by weight. 
     
     
         25 . The composition of  claim 24  wherein the barrier material is selected from the group consisting of aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose, cholecalciferol, cocoa butter, cod liver oil, colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin, live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, pertrolatum, protein hydrolysate, racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate, zinc oxide and combinations of two or more of the foregoing. 
     
     
         26 . A system comprising:
 a dispenser comprising a reservoir and a hand pump; and   the foamable composition of  claim 1  contained within the reservoir.   
     
     
         27 . A method for sanitizing a surface, comprising:
 applying a volume of a non-aerosol foamable composition accordinig to present  claim 1  to a surface, which upon shaking or dispensing from a dispenser forms a foam with a percentage foam volume increase of at least 100%, wherein the composition does not include a propellant, and the foam formed maintains a measurable height for at least 5 seconds following creation of the foam.   
     
     
         28 . The method of  claim 27  wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 20 cps at 23° C. 
     
     
         29 . The method of  claim 27  wherein the surface is human skin. 
     
     
         30 . The method of  claim 27  wherein a discrete volume of stable foam is applied to the surface of the skin and subsequently spread out across the surface of the skin. 
     
     
         31 . The method as defined in  claim 30  further comprising rinsing the surface of the skin with water. 
     
     
         32 . A non-aerosol foamable composition comprising:
 (A) at least 55% by weight of a monohydric alcohol selected from the group consisting of C 2  to C 4  alcohols and combinations of two or more of the foregoing, based on the total weight of the composition;   (B) a dimethicone surfactant selected from the group consisting of PEG/PPG-4/12 dimethicone, PEG/PPG-35/65 dimethicone, PEG/PPG-18/18 dimethicone, hydroxy-terminated PEG-12 dimethicone, hydroxyl-capped dimethicone copolyol, Silicone Quaternary 1, Silicone Quaternary 2, dimethicone copolyol laurate, silicone copolyol pelargonate, dimethicone copolyol lactate, sodium dimethicone copolyol acetyl methyltaurate, PEG/PPG-17/18 dimethicone, silicone copolyol isostearate, methoxy-terminated PEG dimethicone, methoxy-terminated EO/PO dimethicone, hydroxypropyl methyl EO/PO dimethicone copolyol, butoxy-terminated PPO dimethicone, hydroxy-terminated PEG dimethicone, Polysilicone-8, and combinations thereof; and   (C) a component selected from the group consisting of ethylcellulose, PEG-150 pentaerythrityl tetrastearate, PEG-6 capric/caprylic glycerides, hydroxypropyl guar, butylated polyvinyl pyrrolidone, cetyl hydroxyethylcellulose, polyvinyl pyrrolidone, ethylene oxide/propylene oxide block copolymers, poly(ethylene oxide), poly(ethylene oxide, propylene oxide) monoallyl ether acetate, polyether polyol acetate, polyethylene oxide monoallyl ether, polyethylene glycol monoallyl ether acetate, and combinations thereof.   
     
     
         33 . The composition of  claim 32  further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof. 
     
     
         34 . A non-aerosol foam comprising:
 (A) at least 55% by weight of a monohydric alcohol selected from the group consisting of C 2  to C 4  alcohols and combinations of two or more of the foregoing, based on the total weight of the foam;   (B) a dimethicone surfactant selected from the group consisting of PEG/PPG-4/12 dimethicone, PEG/PPG-35/65 dimethicone, PEG/PPG-18/18 dimethicone, hydroxy-terminated PEG-12 dimethicone, hydroxyl-capped dimethicone copolyol, Silicone Quaternary 1, Silicone Quaternary 2, dimethicone copolyol laurate, silicone copolyol pelargonate, dimethicone copolyol lactate, sodium dimethicone copolyol acetyl methyltaurate, PEG/PPG-17/18 dimethicone, silicone copolyol isostearate, methoxy-terminated PEG dimethicone, methoxy-terminated EO/PO dimethicone, hydroxypropyl methyl EO/PO dimethicone copolyol, butoxy-terminated PPO dimethicone, hydroxy-terminated PEG dimethicone, Polysilicone-8, and combinations thereof; and   (C) a component selected from the group consisting of ethylcellulose, PEG-150 pentaerythrityl tetrastearate, PEG-6 capric/caprylic glycerides, hydroxypropyl guar, butylated polyvinyl pyrrolidone, cetyl hydroxyethylcellulose, polyvinyl pyrrolidone, ethylene oxide/propylene oxide block copolymers, poly(ethylene oxide), poly(ethylene oxide, propylene oxide) monoallyl ether acetate, polyether polyol acetate, polyethylene oxide monoallyl ether, polyethylene glycol monoallyl ether acetate, and combinations thereof.   
     
     
         35 . The foam of  claim 34  further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof. 
     
     
         36 . A non-aerosol foamable composition comprising:
 at least 60% by weight of ethanol, based on the weight of the composition;   water;   isopropanol;   a polymer of dimethylsiloxane with polyoxyethylene;   at least one of polyquaternium-1 to polyquaternium-47;   glycerol;   propylene glycol;   fragrance;   butylparaben;   ethylparaben;   methylparaben;   phenoxyethanol; and   propylparaben.   
     
     
         37 . The non-aerosol foamable composition of  claim 36  further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof. 
     
     
         38 . The non-aerosol foamable composition of  claim 36  further comprising a short chain alkyl or aryl ester (C 1 -C 6 ) of a long chain straight or branched chain alkyl or alkenyl alcohol or acid (C 8 -C 32 ) or its polyethoxylated derivative. 
     
     
         39 . A non-aerosol foam comprising:
 at least 60% by weight of ethanol, based on the weight of the foam;   water;   isopropanol;   a polymer of dimethylsiloxane with polyoxyethylene;   at least one of polyquaternium-1 to polyquaternium-47;   glycerol;   propylene glycol;   fragrance;   butylparaben;   ethylparaben;   methylparaben;   phenoxyethanol; and   propylparaben.   
     
     
         40 . The non-aerosol foam of  claim 39  further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof. 
     
     
         41 . The non-aerosol foam of  claim 40  further comprising a short chain alkyl or aryl ester (C 1 -C 6 ) of a long chain straight or branched chain alkyl or alkenyl alcohol or acid (C 8 -C 32 ) or its polyethoxylated derivative.