US2010322961A1PendingUtilityA1

Intranasal Drug Delivery System

27
Assignee: PERRY WAYNE JEFFREYPriority: Mar 30, 2007Filed: Aug 3, 2010Published: Dec 23, 2010
Est. expiryMar 30, 2027(~0.7 yrs left)· nominal 20-yr term from priority
Inventors:Wayne Jeffrey Perry
A61P 37/08A61P 25/34A61P 27/14A61P 29/00A61K 9/0043A61P 13/08A61K 36/81
27
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Claims

Abstract

The present invention provides an intranasal drug delivery system containing capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin in the form of oleoresin capsicum used as a carrier to quickly and effectively deliver a drug.

Claims

exact text as granted — not AI-modified
1 - 24 . (canceled) 
     
     
         25 . An intranasal composition comprising
 purified water; and   a water-soluble oleoresin capsicum including capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin,   wherein the oleoresin capsicum is about 0.000001% to 0.0071% by weight of the total weight of the purified water in the system.   
     
     
         26 . The intranasal composition of  claim 25 , and further comprising
 a drug,   wherein the water-soluble oleoresin capsicum acts as a carrier of the drug and increases the permeability of nasal membranes to the drug.   
     
     
         27 . The delivery system in accordance with  claim 26 , wherein the drug is in liquid form. 
     
     
         28 . The intranasal composition of  claim 25 , wherein the oleoresin capsicum is between about 1 ppb to 50,000 ppb of the system. 
     
     
         29 . The intranasal composition of  claim 25 , wherein capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicins, and homocapsaicin have a heat level of about 100,000 to about 500,000 Scoville units. 
     
     
         30 . The intranasal composition of  claim 26 , wherein the drug is homeopathic. 
     
     
         31 . The intranasal composition of  claim 25 , wherein the water-soluble oleoresin capsicum comprises between about 67-71% capsaicin, about 20-24% dihydrocapsaicin, about 5-9% nordihydrocapsaicin, about 0.25-2% homodihydrocapsaicin, and about 0.25-2% homocapsaicin. 
     
     
         32 . The intranasal composition of  claim 26 , wherein the drug comprises:
 0.13% by weight of the total suspension material weight of eucalyptol;   0.10% by weight of the total suspension material weight of feverfew extract; and   0.0027% by weight of the total suspension material weight of peppermint oil, and   wherein the drug delivery system is effective to relieve at least one symptom associated with headaches or migraines.   
     
     
         33 . The intranasal composition of  claim 32 , and further comprising:
 0.0044% to 0.0047% by weight of the total water weight of water-soluble oleoresin capsicum;   0.08% by weight of the total water weight of rosemary extract;   0.05% by weight of the total water weight of grapefruit seed extract;   3.65% by weight of the total water weight of vegetable glycerin;   0.53% by weight of the total water weight of sea salt;   0.83% by weight of the total water weight of ascorbic acid; and   0.26% by weight of the total water weight of citric acid.   
     
     
         34 . The intranasal composition of  claim 26 , wherein the drug comprises 0.13% by weight of the total water weight of eucalyptol; and 0.10% by weight of the total suspension material weight of nettle. 
     
     
         35 . The intranasal composition of  claim 34 , and further comprising:
 0.0029% to 0.0032% by weight of the total water weight of oleoresin capsicum;   0.09% by weight of the total water weight of rosemary extract;   0.05% by weight of the total water weight of grapefruit seed extract;   3.65% by weight of the total water weight of vegetable glycerin;   0.53% by weight of the total water weight of sea salt;   0.83% by weight of the total water weight of ascorbic acid; and   0.26 by weight of the total water weight of citric acid.   
     
     
         36 . The intranasal composition of  claim 26 , and further comprising 0.20% by weight of the total water weight of licorice root extract; and 0.15% by weight of the total water weight of Chinese ginseng. 
     
     
         37 . The intranasal composition of  claim 36 , and further comprising:
 0.0018% to 0.0021% by weight of the total water weight of the total water weight of oleoresin capsicum;   0.20% by weight of the total water weight of green tea extract;   0.05% by weight of the total water weight of grapefruit seed extract;   3.65% by weight of the total water weight of vegetable glycerin;   0.025% by weight of the total water weight of spearmint oil;   0.83% by weight of the total water weight of ascorbic acid; and   0.26% by weight of the total water weight of citric acid.   
     
     
         38 . The intranasal composition of  claim 26 , wherein the drug comprises 0.120% by weight of the total water weight of echinacea extract; 0.13% by weight of the total water weight of eucalyptol; and 0.15% by weight of the total water weight of golden seal extract based on the total water weight of the base. 
     
     
         39 . The intranasal composition of  claim 38 , and further comprising:
 0.0024% to 0.0027% by weight of the total water weight of oleoresin capsicum;   0.10% by weight of the total water weight of green tea extract;   0.10% by weight of the total water weight of cats claw extract;   0.013% by weight of the total water weight of spearmint oil;   0.05% by weight of the total water weight of grapefruit seed extract;   0.20% by weight of the total water weight of maitake mushroom extract;   3.65% by weight of the total water weight of vegetable glycerin;   0.53% by weight of the total water weight of sea salt;   0.83% by weight of the total water weight of ascorbic acid; and   0.26% by weight of the total water weight of citric acid.   
     
     
         40 . The intranasal composition of  claim 26 , wherein the drug comprises 0.10% by weight of the total water weight of marshmallow root extract; and 0.15% by weight of the total water weight of kava extract. 
     
     
         41 . The intranasal composition of  claim 40 , and further comprising:
 0.0029% by weight of the total water weight of oleoresin capsicum;   0.0-26% by weight of the total water weight of spearmint oil;   0.05% by weight of the total water weight of grapefruit seed extract;   3.65% by weight of the total water weight of vegetable glycerin;   0.83% by weight of the total water weight of ascorbic acid; and   0.26% by weight of the total water weight of citric acid.   
     
     
         42 . The intranasal composition of  claim 26 , wherein the drug comprises 0.030% by weight of the total water weight of chaste berry; 0.10% by weight of the total water weight of wild yam root; 0.025% by weight of the total water weight of fennel; and 0.10% by weight of the total water weight of passion flower. 
     
     
         43 . The intranasal composition of  claim 42 , and further comprising:
 0.0010% to 0.0013% by weight of the total water weight of oleoresin capsicum;   0.30% by weight of the total water weight of don quai extract;   0.025% by weight of the total water weight of spearmint oil;   0.05% by weight of the total water weight of grapefruit seed extract;   3.65% by weight of the total water weight of vegetable glycerin;   0.783% by weight of the total water weight of ascorbic acid; and   0.26% by weight of the total water weight of citric acid.   
     
     
         44 . The intranasal composition of  claim 26 , wherein the drug comprises 0.20% by weight of the total water weight of saw palmetto; 0.026% by weight of the total water weight of pygeum africanum; and 0.026% by weight of the total water weight of Chinese ginseng. 
     
     
         45 . The intranasal composition of  claim 44 , and further comprising:
 0.0023% to 0.0026% by weight of the total water weight of oleoresin capsicum;   0.020% by weight of the total water weight of maitake mushroom extract;   0.010% by weight of the total water weight of pine needle oil;   0.010% by weight of the total water weight of spearmint oil;   0.05% by weight of the total water weight of grapefruit seed extract;   3.65% by weight of the total water weight of vegetable glycerin;   0.783% by weight of the total water weight of ascorbic acid; and   0.26% by weight of the total water weight of citric acid.   
     
     
         46 . A method of delivering a drug to a human, comprising the steps of:
 intranasally administering the composition according to  claim 25  in combination with a drug,   wherein the water-soluble oleoresin capsicum acts to increase the permeability of nasal membranes to the drug.

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