US2010322891A1PendingUtilityA1
Immuniostimulating polyphosphazene compounds
Individually held — no corporate assignee on recordPriority: Feb 18, 2005Filed: Aug 24, 2010Published: Dec 23, 2010
Est. expiryFeb 18, 2025(expired)· nominal 20-yr term from priority
A61P 37/04A61P 31/12A61P 37/00A61P 31/04A61K 31/74A61K 31/80A61K 2039/55555A61K 2039/55511A61K 39/39C08G 79/025C12N 2730/10134A61K 39/292A61K 39/35C12N 7/00A61K 39/00Y02A50/30
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Claims
Abstract
Polyphosphazene polymers having immunomodulating activity, and the biomedical use of such polyphosphazene polymers, in conjunction with an antigen or an immunogen are disclosed.
Claims
exact text as granted — not AI-modified1 . A polyphosphazene polymer comprising the following units:
wherein at least one R has the formula:
wherein:
wherein at least one of C, C′, or C″ includes —COOH; each of d, f, f′, f″, is from 0 to 3; each of e, e′, g, g′, g″ is from 0 to 1
and if
f=0, such that
C═—COOH
then at least one of C′, C″, Y, or Y′ is other than hydrogen; or X is other than —O—; —NH—; or —S—;
and the sum of d+e+e′+f′+f″+g′+g″ equals from 1 to 8.
2 . The polyphosphazene polymer of claim 1 wherein:
and f is 2; d, e, e′, g′ and g″ are 0, and the compound is:
3 . The polyphosphazene polymer of claim 1 wherein:
and f is 1; d, e, e′, g′ and g″ are 0, and the compound is:
4 . The polyphosphazene polymer of claim 1 wherein:
and d is 1; e, e′, f, g′, g″ are 0, and the compound is:
5 . The polyphosphazene polymer of claim 1 wherein:
and e and f are 1; d, e′, g′, and g″ are 0, and the compound is:
6 . The polyphosphazene polymer of claim 1 wherein:
and e is 1; d, e′, f, g′, and g″ are 0, and the compound is:
7 . The polyphosphazene polymer of claim 1 wherein:
and d, e, e′, g′, and g″ are 0, and the compound is:
8 . The polyphosphazene polymer of claim 1 wherein:
and d, e, e′, g, f′, and f″ are 0, and the compound is:
9 . The polyphosphazene polymer of claim 1 wherein:
and f is 2; d, e, e′, g′ and g″ are 0,
and at least a portion of the R side groups are phenoxy groups and the compound is:
wherein and a+b=2.
10 . The polyphosphazene polymer of claim 1 wherein:
and f is 2; d, e, e′, g′ and g″ are 0,
and at least a portion of the R side groups are decoxy groups and the compound is:
and wherein a+b=2.
11 . A composition for inducing an immunogenic response in a human or in an animal comprising at least one polyphosphazene polymer according to claim 1 and an antigen.
12 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the antigen is selected from the group consisting of protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof, said protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof, being derived from the group consisting of cell, bacteria, virus particle, and portions thereof.
13 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex.
14 . A composition for inducing an immunogenic response in a human or in an animal according to claim 13 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex capable of multimeric antigen presentation.
15 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the antigen is covalently conjugated to the polyphosphazene polymer.
16 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the polyphosphazene polymer is ionically cross-linked with multivalent ions to form microparticulate or microgel.
17 . A polyphosphazene polymer comprising the following units:
wherein at least one R has the following formula:
—X—Z
wherein
d is from 0 to 15.
18 . A polyphosphazene polymer according to claim 17 wherein:
and d is 5, and the compound is:
19 . A polyphosphazene polymer according to claim 17 wherein:
and d is 1, and the compound is:
20 . A polyphosphazene polymer according to claim 17 wherein:
and d is 0, and the compound is:
21 . A polyphosphazene polymer according to claim 17 wherein:
and d is 0, and the compound is:
22 . A composition for inducing an immunogenic response in a human or in an animal comprising at least one polyphosphazene polymer according to claim 17 and an antigen.
23 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the antigen is selected from the group consisting of protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof said protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof, being derived from the group consisting of cell, bacteria, virus particle, and portions thereof.
24 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex.
25 . A composition for inducing an immunogenic response in a human or in an animal according to claim 24 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex capable of multimeric antigen presentation.
26 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the antigen is covalently conjugated to the polyphosphazene polymer.
27 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the polyphosphazene polymer is ionically cross-linked with multivalent ions to form microparticulate or microgel.Join the waitlist — get patent alerts
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