Silicone scar treatment preparation

Abstract

Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.

1 ) A spreadable preparation for aiding in the healing of wounds, as well as improving the characteristics of the post-epithelialially developed tissue at the wound site, said preparation comprising:
 a) a volatile component;   b) siloxane matrix precursors; wherein said precursors are capable of forming a siloxane matrix at temperatures in the range of from about 95 to 100 degrees Fahrenheit during evaporation of the volatile component;   c) an active component having low miscibility and low solubility in said siloxane matrix precursors;   d) a volatile coagent;   wherein said volatile coagent is capable of forming a complex with said active component to form a solubilized active component; wherein the complex is miscible in said siloxane matrix precursors; and wherein all or a portion of said volatile coagent evaporates from the preparation upon the formation of the siloxane matrix.   
     
     
         2 ) The spreadable preparation as in  claim 1  wherein the volatile coagent is an ester of a linear acid having a carbon chain length in the range of from about 6 to 13 carbon atoms and methanol, ethanol, or a secondary alcohol having a total carbon content in the range of from about 3 to about 8 carbon atoms. 
     
     
         3 ) The spreadable preparation as in  claim 1  wherein the volatile coagent is a glycol comprised of a linear chain of three or more carbons and one or more hydroxyl groups; and wherein all hydroxyl groups are on adjacent carbons including an end carbon. 
     
     
         4 ) The spreadable preparation as in  claim 1  wherein the volatile coagent is a substituted or unsubstituted isosorbide. 
     
     
         5 ) The spreadable preparation as in  claim 1  wherein the active component comprises an agent having sun screening activity. 
     
     
         6 ) The spreadable preparation as in  claim 1  wherein the active component comprises an agent having antihistamine or pain relieving activity. 
     
     
         7 ) The spreadable preparation as in  claim 5  wherein the active component comprises one or more of the following: Octocrylene (ISP Escalol 597), Octinoxate (ISP Escalol 557), Octisalate (ISP Escalol 587), or Oxybenzone (ISP Escalol 567). 
     
     
         8 ) The spreadable preparation as in  claim 6  wherein the active component comprises Hydrocortisone Acetate USP. 
     
     
         9 ) The spreadable preparation as in  claim 1  wherein the volatile coagent comprises Dimethyl isosorbide 
     
     
         10 ) The spreadable preparation as in  claim 1  wherein the volatile coagent comprises isopropyl myristate. 
     
     
         11 ) The spreadable preparation as in  claim 1  wherein the volatile coagent comprises pentylene glycol. 
     
     
         12 ) The spreadable preparation as in  claim 6  wherein the volatile coagent comprises isopropyl myristate. 
     
     
         13 ) The spreadable preparation as in  claim 8  wherein the volatile coagent comprises Dimethyl isosorbide 
     
     
         14 ) The spreadable preparation as in  claim 13  wherein the volatile coagent comprises pentylene glycol. 
     
     
         15 ) The spreadable preparation as in  claim 1  wherein the siloxane matrix precursors comprise dimethicone crosspolymer, fumed silica, and dimethicone. 
     
     
         16 ) A method as in  claim 1  wherein the volatile component is cyclopentasiloxane. 
     
     
         17 ) A method for the preparation of a spreadable preparation for aiding in the healing of wounds and the development of scar tissue, said preparation comprising:
 a) a volatile component;   b) siloxane matrix precursors; wherein said precursors are capable of forming a siloxane matrix at temperatures in the range of from about 95 to 100 degrees Fahrenheit during evaporation of the volatile component;   c) an active component having low miscibility and low solubility in said siloxane matrix precursors;   d) a volatile coagent;   wherein said volatile coagent is capable of forming a complex with said active component to form a solubilized active component; wherein the complex is miscible in said siloxane matrix precursors; and wherein all or a portion of said volatile coagent evaporates from the preparation upon the formation of the siloxane matrix.   said method comprising the steps of:   a) providing said active component   b) providing said volatile coagent   c) providing siloxane matrix precursors   d) forming a complex between the volatile coagent and said active component which is miscible.   
     
     
         18 ) The method of  claim 17  wherein the siloxane matrix precursors comprise dimethicone crosspolymer, fumed silica, and dimethicone and the volatile component comprises cyclopentasiloxane. 
     
     
         19 ) The method of  claim 17  wherein the volatile coagent comprises isopropyl myristate and the active component comprises one or more of the following: Octocrylene (ISP Escalol 597), Octinoxate (ISP Escalol 557), Octisalate (ISP Escalol 587), or Oxybenzone (ISP Escalol 567). 
     
     
         20 ) The method of  claim 17  wherein the volatile coagent comprises pentylene glycol and/or dimethyl isosorbide and the active component comprises Hydrocortisone Acetate.