plastic container comprising cyclic polyolefin layer

Abstract

The present invention provides and a plastic container and multilayered films, which comprises a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and which further comprises a resin composition layer comprises a blended product of a propylene polymer and a styrene elastomer. The plastic container of the present invention can suppresses a reduction in the medicament content of a liquid-state medicament and is excellent in terms of shock resistance, handling ability during the filling of the container with the medicament, and the moldability and transparency of the container.

1 . A plastic container, which is molded by heat-sealing the peripheral portions of multilayered films each comprising a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and further comprising a resin composition layer comprises a blended product of a propylene polymer and a styrene elastomer, in a state in which the seal layers are laminated on each other such that they face each other. 
     
     
         2 . The plastic container according to  claim 1 , which comprises a resin composition layer or a polyethylene layer on the surfaces of both sides of the cyclic polyolefin layer. 
     
     
         3 . The plastic container according to  claim 1 , which comprises a resin composition layer having a fusion peak temperature only in a temperature range from 120° C. or higher to 170° C. or lower and also having a heat of fusion from 5 J/g or more to 20 J/g or less on the surfaces of both sides of the cyclic polyolefin layer. 
     
     
         4 . The plastic container according to  claim 1 , wherein the cyclic polyolefin of the cyclic polyolefin layer is a ring-opening polymer hydrogenation product of dicyclopentadiene or a derivative thereof. 
     
     
         5 . The plastic container according to  claim 1 , wherein the cyclic polyolefin layer has a glass transition temperature (Tg) of 80° C. to 120° C. 
     
     
         6 . The plastic container according to  claim 1 , wherein the melt flow rate (230° C., 21.2 N) value of the cyclic polyolefin layer is 1 to 20 (g/10 minutes). 
     
     
         7 . The plastic container according to  claim 1 , wherein the melt flow rate (230° C., 21.2 N) value of the seal layer and/or the outermost layer is 1 to 4 (g/10 minutes). 
     
     
         8 . The plastic container according to  claim 1 , wherein the bending elasticity of the seal layer and/or the outermost layer is 400 to 600 MPa. 
     
     
         9 . The plastic container according to  claim 1 , wherein the maximum fusion peak temperature of the seal layer is 125° C. to 135° C. 
     
     
         10 . The plastic container according to  claim 1 , wherein the highest fusion peak temperature of the seal layer is 150° C. to 160° C. 
     
     
         11 . The plastic container according to  claim 1 , wherein the fusion peak temperature of the outermost layer is 160° C. to 170° C. 
     
     
         12 . The plastic container according to  claim 1 , wherein the plastic film has a tensile elasticity of 300 MPa or less. 
     
     
         13 . The plastic container according to  claim 1 , which can be sterilized at 115° C. for 30 minutes or more. 
     
     
         14 . The plastic container according to  claim 1 , which can be sterilized at 121° C. for 15 minutes or more. 
     
     
         15 . The plastic container according to  claim 1 , which is filled with a solution comprising, as an active ingredient, a pyrazolone derivative represented by the formula (I) as shown below, a physiologically acceptable salt thereof, a hydrate thereof, or a solvate thereof: 
       
         
           
           
               
               
           
         
       
       wherein R 1  represents a hydrogen atom, an aryl, an alkyl containing 1 to 5 carbon atoms, or an alkoxycarbonylalkyl containing 3 to 6 carbon atoms in total; R 2  represents a hydrogen atom, an aryloxy, an arylmercapto, an alkyl containing 1 to 5 carbon atoms, or a hydroxyalkyl containing 1 to 3 carbon atoms; or R 1  and R 2  together represent an alkylene containing 3 to 5 carbon atoms; R 3  represents a hydrogen atom, an alkyl containing 1 to 5 carbon atoms, a cycloalkyl containing 5 to 7 carbon atoms, a hydroxyalkyl containing 1 to 3 carbon atoms, a benzyl, naphthyl or phenyl, or a phenyl substituted with 1 to 3 identical or different substituents selected from the group consisting of an alkoxy containing 1 to 5 carbon atoms, a hydroxyalkyl containing 1 to 3 carbon atoms, an alkoxycarbonyl containing 2 to 5 carbon atoms in total, an alkylmercapto containing 1 to 3 carbon atoms, an alkylamino containing 1 to 4 carbon atoms, a dialkylamino containing 2 to 8 carbon atoms in total, a halogen atom, a trifluoromethyl, a carboxyl, a cyano, a hydroxyl group, a nitro, an amino, and an acetamide. 
     
     
         16 . The plastic container according to  claim 15 , wherein the pyrazolone derivative represented by the formula (I) is 3-methyl-1-phenyl-2-pyrazolin-5-one. 
     
     
         17 . The plastic container according to  claim 1 , which is in the form of an infusion bag. 
     
     
         18 . The plastic container according to  claim 1 , which is placed together with an oxygen absorber into a poorly air-permeable container. 
     
     
         19 . A multilayered film, which comprises a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and which further comprises a resin composition layer comprises a blended product of a propylene polymer and a styrene elastomer; provided that a five-layered plastic film composed of only a seal layer-an adhesive layer-a barrier layer-an adhesive layer-a material layer, wherein each of the seal layer and the material layer consists of only a polypropylene elastomer having a melting point of 165° C., each of the adhesive layers consists of only MODIC manufactured by Mitsubishi Chemical Corporation, and the barrier layer consists of only a cyclic polyolefin polymer having a glass transition temperature of 136° C., is excluded.