US2010317712A1PendingUtilityA1
Estrogen Agonists/Antagonists For Preventing Breast Cancer
Individually held — no corporate assignee on recordPriority: Jan 9, 1995Filed: Aug 20, 2010Published: Dec 16, 2010
Est. expiryJan 9, 2015(expired)· nominal 20-yr term from priority
A61P 9/00A61P 5/32A61P 35/00A61P 5/30A61P 7/00A61P 3/06A61P 5/00C07D 295/088C07D 213/64C07D 217/16A61K 31/40C07D 401/04A61P 19/10C07D 207/40C07D 295/155
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Claims
Abstract
Compounds of this formula are useful for preventing breast cancer.
Claims
exact text as granted — not AI-modified1 - 4 . (canceled)
5 . (−)-Cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol hydrochloride salt.
6 . A pharmaceutical composition comprising a therapeutically effective amount of (−)-Cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol hydrochloride salt together with a diluent, binder, lubricant and disintegrator.
7 . A process for preparing (−)-Cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol hydrochloride salt, the process comprising partitioning the R-binap salt of (−)-Cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-5,6,7,8-tetrahydro naphthalen-2-ol between 1:2 methanol:methylene chloride and 1% aqueous sodium hydroxide to afford the (−)-Cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol free base which is then treated with hydrochloric acid in dioxane followed by recrystallization from acetonitrile/methylene chloride to provide (−)-Cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol hydrochloride salt.Join the waitlist — get patent alerts
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