Polymorph, polymorph screening system, and polymorph preparing and screening method

Abstract

A polymorph, a polymorph screening system, and a polymorph preparing and screening method are disclosed. The polymorph preparing and screening method includes the following steps: providing a plurality of substrates of different materials; causing an organic material to grow crystals on the plurality of substrates through solution-cooling crystallization process, so that a plurality of polymorphs with different characteristics are prepared; and screening the plurality of polymorphs prepared in the previous step to obtain polymorphs with desired characteristics.

1 . A polymorph screening system, comprising:
 a plurality of substrates made of different materials respectively;   a solution-cooling crystallizing unit arranged for causing an organic material to grow crystals on the plurality of substrates, so as to prepare a plurality of polymorphs having different characteristics; and   a characteristic analyzing unit arranged for screening the plurality of prepared polymorphs to obtain polymorphs with a desired characteristic.   
     
     
         2 . The polymorph screening system as claimed in  claim 1 , wherein the plurality of substrates are disposed on a same base plate. 
     
     
         3 . The polymorph screening system as claimed in  claim 2 , wherein the plurality of substrates are arranged as a chip-based array. 
     
     
         4 . The polymorph screening system as claimed in  claim 1 , wherein the plurality of substrates are selected from the group consisting of a semiconductor wafer substrate, a polymeric substrate, a thin-film substrate, a glass substrate, and a plastic substrate; and the substrates are different in crystallographic face. 
     
     
         5 . The polymorph screening system as claimed in  claim 4 , wherein the plurality of substrates are selected from the group consisting of polystyrene, polystyrene-polybutadiene-polystyrene, an eggshell membrane, a gold film, and a silicon wafer. 
     
     
         6 . The polymorph screening system as claimed in  claim 1 , wherein the organic material is a small-molecular organic material. 
     
     
         7 . The polymorph screening system as claimed in  claim 6 , wherein the small-molecular organic material is selected from the group consisting of a semiconductor material and a biomedical material. 
     
     
         8 . The polymorph screening system as claimed in  claim 7 , wherein the semiconductor material is selected from the group consisting of 1,1-Bi-2-naphthol and tris-(8-hydroxyquinoline) aluminum (III). 
     
     
         9 . The polymorph screening system as claimed in  claim 7 , wherein the biomedical material is selected from the group consisting of DL-aspartic acid and cytosine. 
     
     
         10 . The polymorph screening system as claimed in  claim 1 , wherein the characteristic analyzing unit is selected from the group consisting of a differential scanning calorimeter (DSC), an optical microscope (OM), a Fourier transform infrared spectroscope (FT-IR), an X-ray diffractometer (XRD), and any combination thereof. 
     
     
         11 . A polymorph preparing and screening method, comprising the following steps:
 providing a plurality of substrates made of different materials respectively;   causing an organic material to grow crystals on the plurality of substrates through a solution-cooling crystallization process, so that a plurality of polymorphs with different characteristics are prepared; and   screening the plurality of polymorphs prepared in the previous step to obtain polymorphs with a desired characteristic.   
     
     
         12 . The polymorph preparing and screening method as claimed in  claim 11 , wherein the plurality of substrates are disposed on a same base plate. 
     
     
         13 . The polymorph preparing and screening method as claimed in  claim 12 , wherein the plurality of substrates are arranged as a chip-based array. 
     
     
         14 . The polymorph preparing and screening method as claimed in  claim 11 , wherein the plurality of substrates are selected from the group consisting of a semiconductor wafer substrate, a polymeric substrate, a thin-film substrate, a glass substrate, and a plastic substrate; and the substrates are different in crystallographic face. 
     
     
         15 . The polymorph preparing and screening method as claimed in  claim 14 , wherein the plurality of substrates are selected from the group consisting of polystyrene, polystyrene-polybutadiene-polystyrene, an eggshell membrane, a gold film, and a silicon wafer. 
     
     
         16 . The polymorph preparing and screening method as claimed in  claim 11 , wherein the organic material is a small-molecular organic material. 
     
     
         17 . The polymorph preparing and screening method as claimed in  claim 16 , wherein the small-molecular organic material is selected from the group consisting of a semiconductor material and a biomedical material. 
     
     
         18 . The polymorph preparing and screening method as claimed in  claim 17 , wherein the semiconductor material is selected from the group consisting of 1,1-Bi-2-naphthol and tris-(8-hydroxyquinoline) aluminum (III). 
     
     
         19 . The polymorph preparing and screening method as claimed in  claim 17 , wherein the biomedical material is selected from the group consisting of DL-aspartic acid and cytosine. 
     
     
         20 . A polymorph being prepared using the polymorph preparing and screening method as claimed in  claim 11 .