Self-Neutralizing Acid Peel for Dermatologic Use

Abstract

A dermatologic peel comprising alpha hydroxyl acid and metal hydroxide nanocomplexes as neutralizing agents to continually reduce the activity of the system when the acid and neutralizer components are mixed. For example, a 30% glycolic acid gel mixed with a fluidized magaldrate neutralizer can be applied to the skin and will self-neutralize to a skin-compatible pH within a few minutes, effectively exfoliating the skin without a separate neutralization step. The peel is advantageously applied from a two-component system that mixes the components.

1 . A two-component system for preparing a self-neutralizing dermatologic peel composition by mixing the components prior to application to the skin, said system comprising a first container of at least one alpha hydroxy acid component and a second container of neutralizer component, the acid component characterized by establishing an initial free acid concentration efficacious for a dermatologic peel upon first mixing with the neutralizer component prior to application to the skin, and the neutralizer component characterized by reducing the initial free acid concentration of the composition while applied to the skin at a rate sufficient to increase the pH of the composition to a substantially skin-compatible composition and substantially stop the exfoliation in a predetermined treatment time. 
     
     
         2 . The system of  claim 1  wherein said first and second containers are piston-actuated dispensing tubes fitted with pistons. 
     
     
         3 . The system of  claim 1  wherein said free acid concentration is the bioavailable acid concentration. 
     
     
         4 . The system of  claim 1  wherein said alpha hydroxy acid component comprises glycolic acid. 
     
     
         5 . The system of claim t wherein said neutralizer component comprises magaldrate. 
     
     
         6 . The system of  claim 1  wherein said neutralizer component comprises at least one insoluble inorganic metal hydroxide. 
     
     
         7 . The system of  claim 1  wherein said alpha hydroxy acid component contains acid in a concentration of from about 15% to about 70% by weight prior to mixing with said neutralizer component. 
     
     
         8 . The composition of  claim 7  wherein said acid component comprises in addition to the acid a neutralizer component in a shelf-stable formulation. 
     
     
         9 . The composition of  claim 1  wherein said neutralizer component is microfluidized. 
     
     
         10 . The composition of  claim 1  wherein said neutralizer component is microfluidized magaldrate. 
     
     
         11 . The composition of  claim 10  wherein said magaldrate is microfluidized at a pressure of from 2000 to 7500 psi. 
     
     
         12 . The composition of  claim 10  wherein said magaldrate is microfluidized at a pressure of about 5000 psi. 
     
     
         13 . The composition of  claim 1  wherein said predetermined treatment time is about 2 to 10 minutes. 
     
     
         14 . The composition of  claim 6  wherein said inorganic metal hydroxide is aluminum hydroxide.