Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase

Abstract

The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.

1 . A regime or regimen for increasing the endogenous synthesis of superoxide dismutase in an individual subject in need of such treatment, comprising administering to such individual subject a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         2 . A regime or regimen for preventing and/or limiting the formation of free radicals and/or eliminating free radicals present in cells of an individual subject in need of such treatment, comprising administering to such individual subject a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         3 . A regime or regimen for preventing and/or combating the harmful effects of UV radiation and/or pollution on the skin, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         4 . A regime or regimen for preventing and/or treating the loss of firmness and/or of elasticity of the skin, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         5 . A regime or regimen for preventing and/or treating dull skin complexion, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         6 . A regime or regimen for preventing and/or treating skin dehydration, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         7 . A regime or regimen for preventing and/or treating the signs of epidermal skin aging, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         8 . A regime or regimen as defined by  claim 7 , said signs of epidermal skin aging comprising pigmented spots and/or hyperkeratosis spots and/or epidermal atrophy and/or skin roughness and/or skin drying. 
     
     
         9 . A regime or regimen for preventing and/or limiting and/or eliminating the peroxidation of skin lipids, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         10 . (canceled) 
     
     
         11 . A regime or regimen for photoprotecting the skin against the damaging effects of solar UV radiation, comprising topically applying thereon a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         12 . A regime or regimen for attenuating and/or repairing skin redness and/or skin irritation and/or sensations of overheating of the skin caused by solar radiation, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         13 . A regime or regimen for revitalizing the scalp and improving the appearance of the hair, comprising topically applying thereon a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         14 . A regime or regimen for revitalizing the nails, comprising topically applying thereon a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         15 . The regime or regimen as defined by  claim 1 , said at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium comprising a lipopolysaccharide isolate. 
     
     
         16 . The regime or regimen as defined by  claim 1 , said at least one nonfruiting nonphotosynthetic filamentous bacterium comprising  Vitreoscilla filiformis.    
     
     
         17 . The regime or regimen as defined by  claim 1 , comprising increasing the endogenous synthesis of superoxide dismutase SOD type 2 (MnSOD). 
     
     
         18 . The regime or regimen as defined by  claim 1 , comprising coadministering an effective amount of at least one antioxidant to such individual subject. 
     
     
         19 . The regime or regimen as defined by  claim 18 , said at least one antioxidant comprising lycopene. 
     
     
         20 . The regime or regimen as defined by  claim 18 , said at least one antioxidant comprising superoxide dismutase. 
     
     
         21 . The regime or regimen as defined by  claim 1 , comprising topically applying said effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium onto the skin of such individual subject. 
     
     
         22 . A regime or regimen for treating skin erythema or skin oedema, comprising topically applying onto the afflicted skin of an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         23 . A regime or regimen for treating psoriasis, comprising topically applying onto the afflicted skin of an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         24 . A regime or regimen for inhibiting the development of cancerous skin tumors, comprising topically applying onto the skin of an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         25 . A regime or regimen for preventing and/or limiting and/or eliminating the oxidation phenomena caused by colonization of the skin by microorganisms, comprising topically applying onto the afflicted skin of an individual subject in need of such treatment, a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium. 
     
     
         26 . A topically applicable cosmetic/dermatological composition suited for increasing the endogenous synthesis of superoxide dismutase, comprising a thus effective amount of at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium, formulated into a topically applicable, physiologically acceptable medium therefor. 
     
     
         27 . The cosmetic/dermatological composition as defined by  claim 26 , further comprising an effective amount of at least one antioxidant. 
     
     
         28 . The cosmetic/dermatological composition as defined by  claim 27 , said at least one antioxidant comprising lycopene. 
     
     
         29 . The cosmetic/dermatological composition as defined by  claim 26 , further comprising an effective amount of at least one catalase. 
     
     
         30 . The cosmetic/dermatological composition as defined by  claim 26 , further comprising an effective amount of at least one peroxidase. 
     
     
         31 . The cosmetic/dermatological composition as defined by  claim 26 , further comprising effective amounts of at least one catalase and at least one peroxidase. 
     
     
         32 . The cosmetic/dermatological composition as defined by  claim 26 , comprising an effective amount of at least one extract of  Vitreoscilla filiformis.    
     
     
         33 . The cosmetic/dermatological composition as defined by  claim 26 , further comprising an effective amount of at least one UV sunscreen. 
     
     
         34 . The cosmetic/dermatological composition as defined by  claim 26 , further comprising an effective amount of at least one desquamating and/or moisturizing agent; depigmenting or propigmenting agent; antiglycation agent; agent stimulating the synthesis of dermal or epidermal macromolecules and/or preventing degradation thereof; agent stimulating the proliferation of fibroblasts and/or keratinocytes or stimulating the differentiation of keratinocytes; muscle relaxant; antipollution and/or anti-free radical agent; slimming agent; agent acting on the microcirculation; agent acting on the energy metabolism of the cells; tightening agent; or mixture thereof. 
     
     
         35 . The cosmetic/dermatological composition as defined by  claim 26 , further comprising an effective amount of at least one α-hydroxy acid; salicyclic acid or derivative thereof; HEPES; procysteine; O-octanoyl-6-D-maltose; disodium salt of methylglycinediacetic acid; ceramide; steroid; kojic acid; N-ethyloxycarbonyl-4-para-aminophenol; ascorbic acid or derivative thereof; bilberry extract; retinoid; polypeptide or acylated derivative thereof; phytohormone; extract of the yeast  Saccharomyces cerevisiae ; extract of algae; extract of soyabean, lupin, maize and/or pea; alverine or salt thereof; resveratrol; carotenoid; tocopherol or ester thereof; coenzyme Q10 or ubiquinone; xanthins; extract of butcher=s broom or of horse chestnut; or mixture thereof. 
     
     
         36 . The cosmetic/dermatological composition as defined by  claim 26 , formulated as a solution, emulsion, gel, paste, solid, cream, ointment, milk, serum, lotion, mousse, or aerosol. 
     
     
         37 . The cosmetic/dermatological composition as defined by  claim 28 , comprising from 0.001% to 10% by dry weight of said at least one extract of at least one nonfruiting nonphotosynthetic filamentous bacterium and from 10-9% to 0.1% by weight of lycopene.