Medicaments

Abstract

Methods of prevention or treatment of renal diseases or conditions associated with abnormal ion flux, in particular autosomal dominant polycystic kidney disease, with a modulator of human peroxisome proliferator activated receptor gamma.

1 . A method for treating a renal disease or a condition associated with abnormal ion flux in a mammal, the method comprising the step of administering to the mammal a thiazolidinedione, or a salt or a solvate thereof. 
     
     
         2 . The method of  claim 1  wherein the thiazolidinedione is pioglitazine, rosiglitazone, or a combination thereof, or a salt or a solvate thereof. 
     
     
         3 . The method of  claim 1  wherein the disease or condition is autosomal dominant polycystic kidney disease. 
     
     
         4 . The method of  claim 1  wherein the mammal is a human. 
     
     
         5 . A pharmaceutical composition for treating a renal disease or a condition associated with abnormal ion flux in a mammal, the composition comprising a therapeutically effective amount of one or more thiazolidinediones or salts or solvates thereof, and one or more pharmaceutically acceptable carriers, diluents, eluents, or a combination thereof. 
     
     
         6 . The composition of  claim 5  wherein the one or more thiazolidinediones include pioglitazone or rosiglitazone, or a combination thereof, or a salt or a solvate thereof. 
     
     
         7 . The composition of  claim 5  wherein the disease or condition is autosomal dominant polycystic kidney disease. 
     
     
         8 . The composition of  claim 5  wherein the mammal is a human.