Preparation of radiolabelled haloaromatics via polymer-bound intermediates

Abstract

According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiolabelled haloaromatics are disclosed, as well as processes for the preparation of the intermediate precursor insoluble polymer compounds.

1 . A process of preparing a radiolabelled haloaromatic compound (I) of the formula: 
       
         
           
           
               
               
           
         
         wherein, 
         R2 is selected from an alkyl group, an aryl group, a hydrogen atom, a halogen atom, a substituted oxygen atom, a substituted nitrogen atom, a substituted sulfur atom, a carbonyl group, a cyano group, an amino group, and a guanidino group; 
         *X is selected from any suitable radiohalide; 
         said process comprising reacting a radiohalogen ion with a insoluble polymer compound (II) in the presence of a solvent and an oxidant, said polymer compound (II) having the formula: 
       
       
         
           
           
               
               
           
         
       
       wherein,
 R1 is an alkyl group; and 
 R2 is as described above. 
 
     
     
         2 - 23 . (canceled)