Peptides of il-2

Abstract

The present invention relates to new peptides of IL-2, derivatives thereof, and their use as therapeutic agents.

1 .- 25 . (canceled) 
     
     
         26 . A method of inducing SHC phosphorylation or inducing the SHC/MAPK pathway comprising administering to a subject in need thereof an effective amount of a peptide consisting of SEQ ID NO: 2 or a peptide consisting of SEQ ID NO: 2 containing one conservative mutation, wherein said peptide binds to the IL-2β chain or the monoclonal antibodies produced by H2-8 hybridoma. 
     
     
         27 . The method of  claim 26 , wherein said peptide consists of SEQ ID NO.: 2. 
     
     
         28 . The method of  claim 26 , wherein said peptide is the peptide consisting of SEQ ID NO: 2 containing one conservative mutation. 
     
     
         29 . The method of  claim 28 , wherein said conservative mutation is a replacement of a non-polar R-group by another non-polar R-group. 
     
     
         30 . The method of  claim 28 , wherein said conservative mutation is a replacement of a uncharged non-polar R-group by another uncharged non-polar R-group. 
     
     
         31 . The method of  claim 28 , wherein said conservative mutation is a replacement of a charged polar R-group by another charged polar R-group. 
     
     
         32 . The method of  claim 28 , wherein Lys is substituted for Arg, or vice versa so that a positive charge is maintained. 
     
     
         33 . The method of  claim 28 , wherein Glu is substituted for Asp, or vice versa so that a negative charge is maintained. 
     
     
         34 . The method of  claim 28 , wherein Asp is substituted for Glu. 
     
     
         35 . The method of  claim 28 , wherein one or more Ser is substituted for Thr. 
     
     
         36 . The method of  claim 28 , wherein one or more Gln is substituted for Asn. 
     
     
         37 . The method of  claim 26 , wherein said method is a method of inducing SHC phosphorylation. 
     
     
         38 . The method of  claim 26 , wherein said method is a method of inducing the SHC/MAPK pathway.