Staphylococcus epidermidis nucleic acids and proteins

Abstract

S epidermidis polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides and DNA (RNA) for the treatment of infection, particularly infections arising from S epidermidis . Antagonists against the function of such polypeptides and their use as therapeutics to treat infection are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of S epidermidis nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides and polypeptides related to S epidermidis

1 - 29 . (canceled) 
     
     
         30 . An isolated polynucleotide comprising a member selected from the group consisting of:
 (a) a polynucleotide encoding a polypeptide having at least a 70% identity to a polypeptide set forth in the Sequence Listing as SEQ. ID. NO 2494;   (b) a polynucleotide which is complementary to the polynucleotide of (a); and   (c) a polynucleotide comprising at least 15 sequential bases of the polynucleotide of (a) or (b).   
     
     
         31 . The polynucleotide of  claim 30  wherein the polypeptide has at least 80% identity to the polypeptide set forth in the Sequence Listing. 
     
     
         32 . The polypeptide of  claim 31  wherein the polypeptide has at least 90% identity to the polypeptide set forth in the Sequence Listing. 
     
     
         33 . The polynucleotide of  claim 30  wherein the polynucleotide is DNA. 
     
     
         34 . The polynucleotide of  claim 30  wherein the polynucleotide is RNA. 
     
     
         35 . The polynucleotide of  claim 33  wherein the polynucleotide has at least 80% identity to the polynucleotide set forth in the Sequence Listing as SEQ. ID. No. 2494. 
     
     
         36 . A polypeptide comprising an amino acid sequence which is at least 70% identical to a polypeptide set forth in the Sequence Listing as SEQ. ID. No 2494. 
     
     
         37 . The polypeptide of  claim 36  further comprising an amino acid sequence which is at least 80% identical to a polypeptide set forth in the Sequence Listing. 
     
     
         38 . The polypeptide of  claim 37  further comprising an amino acid sequence which is at least 90% identical to a polypeptide set forth in the Sequence Listing. 
     
     
         39 . The polypeptide of  claim 38  further comprising an amino acid sequence as set forth in the Sequence Listing as SEQ. ID. No. 2494. 
     
     
         40 . A method for inducing an immunological response in a mammal which comprises administering to the mammal the polypeptide of  claim 36 , or a fragment or variant thereof. 
     
     
         41 . An immunological composition comprising a DNA capable of expressing a polypeptide of  claim 36  which, when introduced into a mammal, induces an immunological response in the mammal, and a pharmaceutically acceptable carrier. 
     
     
         42 . An immunological composition comprising a polypeptide of  claim 36  which, when introduced into a mammal, induces an immunological response in the mammal, and a pharmaceutically acceptable carrier.