Herbal composition for treatment of neurodegeneration and neuronal dysfunction

Abstract

This invention provides methods of using various herbal compositions to treat neurodegenerative diseases and neuronal dysfunctions, said compositions comprise a combination of Radix angelica sinensis (DangGui), Ligusticum chuanxiong (ChuanXiong), Hirudo (ShuiZhi), Polygonatum sibiricum (HuangJing), Carthamus tinctorius (Hong Hua), Astragalus membranaceus (HuangQi), and Glycyrrhiza uralensis (Gancao).

1 . A method of treating neurodegenerative diseases selected from the group consisting of motor neuron disease, cerebral palsy, Olivopontocerebellar atrophy, and ataxia, comprising the step of administering to a patient in need thereof a compositing consisting essentially of Radix  angelica sinensis  (DangGui) 0.8-1.9 g/Kg body weight,  Ligusticum chuanxiong  (ChuanXiong) 0.1-0.49 g/Kg body weight,  Hirudo  (ShuiZhi) 0.1-0.28 g/Kg body weight,  Astragalus membranaceus  (HuangQi) 0.315-0.9 g/Kg body weight,  Paeonia rubrae  (ChiShao) 0.1-0.45 g/kg body weight,  Lycium  chinense mill (GouQiZi) 0.1-0.28 g/Kg body weight,  Polygonatum sibiricum  (HuangJing) 0.1-0.45 g/Kg body weight,  Curculigo orchioides  (XianMao) 0.1-0.28 g/Kg body weight,  Epimedium grandiflorum  (YinYangHuo) 0.1-0.19 g/Kg body weight,  Plastrum testudinis  (GuiBan) 0.1-0.30 g/Kg body weight,  Cornus officinalis  (ShanZhuYu) 0.1-0.19 g/Kg body weight,  Psoralea corylifolia  (BuGuZhi) 0.1-0.29 g/Kg body weight,  Leonurus heterophyllus  (YiMuCao) 0.1-0.45 g/Kg body weight,  Glycyrrhiza uralensis  (Gancao) 0.06-0.14 g/Kg body weight,
 wherein the g/kg body weight dosages can be increased up to 2.5 times if the body weight of the patient is less than 40 kg.   
     
     
         2 . The method of  claim 1 , wherein  Ligusticum chuanxiong  (ChuanXiong) is replaced by  Carthamus tinctorius  (Hong Hua) 0.1-0.49 g/kg body weight. 
     
     
         3 . The method of  claim 1 , wherein the composition is administered daily. 
     
     
         4 . A method of treating motor neuron disease comprising the step of administering to a patient in need thereof a compositing consisting essentially of Radix  angelica sinensis  (DangGui) 0.8-1.9 g/Kg body weight,  Ligusticum chuanxiong  (ChuanXiong) 0.1-0.49 g/Kg body weight,  Hirudo  (ShuiZhi) 0.1-0.28 g/Kg body weight,  Astragalus membranaceus  (HuangQi) 0.315-0.9 g/Kg body weight,  Paeonia rubrae  (ChiShao) 0.1-0.45 g/kg body weight,  Lycium  chinense mill (GouQiZi) 0.1-0.28 g/Kg body weight,  Polygonatum sibiricum  (HuangJing) 0.1-0.45 g/Kg body weight,  Curculigo orchioides  (XianMao) 0.1-0.28 g/Kg body weight,  Epimedium grandiflorum  (YinYangHuo) 0.1-0.19 g/Kg body weight,  Plastrum testudinis  (GuiBan) 0.1-0.30 g/Kg body weight,  Cornus officinalis  (ShanZhuYu) 0.1-0.19 g/Kg body weight,  Psoralea corylifolia  (BuGuZhi) 0.1-0.29 g/Kg body weight,  Leonurus heterophyllus  (YiMuCao) 0.1-0.45 g/Kg body weight,  Glycyrrhiza uralensis  (Gancao) 0.06-0.14 g/Kg body weight,
 wherein the g/kg body weight dosages can be increased up to 2.5 times if the body weight of the patient is less than 40 kg.   
     
     
         5 . The method of  claim 4 , wherein  Ligusticum chuanxiong  (ChuanXiong) is replaced by  Carthamus tinctorius  (Hong Hua) 0.1-0.49 g/Kg body weight. 
     
     
         6 . The method of  claim 4 , wherein the composition is administered daily.